HCSGD entry for DMPK

1. General information

Official gene symbolDMPK
Entrez ID1760
Gene full namedystrophia myotonica-protein kinase
Other gene symbolsDM DM1 DM1PK DMK MDPK MT-PK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002028Regulation of sodium ion transportIEAbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005640Nuclear outer membraneIEAcellular_component
GO:0005789Endoplasmic reticulum membraneISScellular_component
GO:0005829CytosolISScellular_component
GO:0005886Plasma membraneISScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006874Cellular calcium ion homeostasisISSbiological_process
GO:0006998Nuclear envelope organizationIMPbiological_process
GO:0008016Regulation of heart contractionIDAbiological_process
GO:0010657Muscle cell apoptotic processIDAbiological_process
GO:0010830Regulation of myotube differentiationISSbiological_process
GO:0014722Regulation of skeletal muscle contraction by calcium ion signalingIEAbiological_process
GO:0014853Regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contractionIEAbiological_process
GO:0017020Myosin phosphatase regulator activityIDAmolecular_function
GO:0031072Heat shock protein bindingIEAmolecular_function
GO:0031307Integral component of mitochondrial outer membraneIDAcellular_component
GO:0031965Nuclear membraneISScellular_component
GO:0033017Sarcoplasmic reticulum membraneISScellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0051823Regulation of synapse structural plasticityIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.37959044110.28608740170.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1062052533
GSE13712_SHEARUp0.3279996402
GSE13712_STATICDown-0.0857704682
GSE19018Up0.1066060396
GSE19899_A1Down-0.3752700670
GSE19899_A2Up0.2306589977
PubMed_21979375_A1Down-0.1386163162
PubMed_21979375_A2Up0.1862934891
GSE35957Up0.7499880403
GSE36640Up0.2064170359
GSE54402Up0.0141000352
GSE9593Up0.3987081102
GSE43922Down-0.6464940956
GSE24585Up0.0916644401
GSE37065Up0.0438423680
GSE28863_A1Down-0.2865931048
GSE28863_A2Down-0.1930772782
GSE28863_A3Down-0.5172165766
GSE28863_A4Down-0.0258093421
GSE48662Up0.4805118605

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-DioneDB01946 EXPT00704

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017260MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.