HCSGD entry for AFP
1. General information
| Official gene symbol | AFP |
|---|---|
| Entrez ID | 174 |
| Gene full name | alpha-fetoprotein |
| Other gene symbols | FETA HPAFP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001542 | Ovulation from ovarian follicle | IEA | biological_process |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0042448 | Progesterone metabolic process | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0060395 | SMAD protein signal transduction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3285885833 | 0.7310683827 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2896668540 |
| GSE13712_SHEAR | Down | -0.0569655515 |
| GSE13712_STATIC | Up | 0.3683919928 |
| GSE19018 | Up | 0.1968255392 |
| GSE19899_A1 | Up | 0.0716875963 |
| GSE19899_A2 | Down | -0.2414192439 |
| PubMed_21979375_A1 | Down | -0.3515400397 |
| PubMed_21979375_A2 | Down | -0.1210906372 |
| GSE35957 | Up | 0.2637744710 |
| GSE36640 | Up | 0.7234928458 |
| GSE54402 | Down | -0.1313948276 |
| GSE9593 | Up | 0.4712283073 |
| GSE43922 | Down | -0.0334877720 |
| GSE24585 | Down | -0.1803426008 |
| GSE37065 | Down | -0.0531896874 |
| GSE28863_A1 | Up | 0.0927282934 |
| GSE28863_A2 | Up | 0.0403759768 |
| GSE28863_A3 | Up | 0.1293524412 |
| GSE28863_A4 | Down | -0.0746937670 |
| GSE48662 | Down | -0.1639115410 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020427 | Microarray | Functional MTI (Weak) | 17242205 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21562774 | The iPSC clones could differentiate to cells originated from all three germ-cell layers, as shown by RT-PCR, for messenger RNA (mRNA) expression of alpha-fetoprotein (endoderm), MSX1 (mesoderm) and microtubule-associated protein 2 (ectoderm), and by immunostaining for alpha-fetoprotein (endoderm), alpha-smooth muscle actin (mesoderm), and beta-III-tubulin (ectoderm) |
| 19726080 | They showed gene expression of alpha-fetoprotein and albumin in a time-dependent manner of the hepatic differentiation process |
| 14522900 | In this study, we found that a subset of ING family members strongly repressed human alpha-fetoprotein (AFP) promoter activity but stimulated the p21(WAF1) promoter in parallel experiments in the same cell type, similar to the effects of p53 |
| 14522900 | In this study, we found that a subset of ING family members strongly repressed human alpha-fetoprotein (AFP) promoter activity but stimulated the p21(WAF1) promoter in parallel experiments in the same cell type, similar to the effects of p53 |
| 14522900 | The p47(ING1a) isoform also repressed AFP promoter activity, but in contrast to other ING isoforms, it repressed the p21(WAF1) promoter |
| 14522900 | Suppression of AFP gene transcription by ING was strongly dependent on AT-motifs that bind to the hepatocyte nuclear factor 1 (HNF1) transcription factor |
| 14522900 | Both ING1 and p53 were able to suppress AFP transcription and cause p21 induction; hSIR2, a negative regulator of the p53 protein, showed the opposite effects on the AFP promoter and, like HDAC1, repressed p21 promoter activity |
| 14522900 | Both ING1 and p53 were able to suppress AFP transcription and cause p21 induction; hSIR2, a negative regulator of the p53 protein, showed the opposite effects on the AFP promoter and, like HDAC1, repressed p21 promoter activity |
| 14522900 | In addition, we found that p33(ING1b) physically interacts with hSIR2, reverses its ability to induce the AFP promoter, and induces acetylation of p53 residues at Lys(373) and/or Lys(382) |
| 14522900 | These findings provide novel evidence that p33(ING1b) represses AFP transcription by at least two mechanisms, one of which includes p53 |
| 11237869 | When transfected into human HepG2 cells, both cDcoH and cDcoHalpha showed similar functional activity as measured by increased expression of a reporter gene, as well as alpha-fetoprotein and albumin genes that both contain HNF-1 binding elements in their promoters |
| 7532927 | The inhibition of apoptosis by alpha-fetoprotein (AFP) and the role of AFP receptors in anti-cellular senescence |
| 7532927 | The inhibition of apoptosis by alpha-fetoprotein (AFP) and the role of AFP receptors in anti-cellular senescence |
| 7532927 | The inhibition of apoptosis by alpha-fetoprotein (AFP) and the role of AFP receptors in anti-cellular senescence |
| 7532927 | The mechanism of paradoxical growth enhancement by alpha-fetoprotein (AFP), a nonmitogenic factor, was explored in HL-60 cells using novel AFP agonists, the 167H |
| 7532927 | The mechanism of paradoxical growth enhancement by alpha-fetoprotein (AFP), a nonmitogenic factor, was explored in HL-60 cells using novel AFP agonists, the 167H |
| 7532927 | The mechanism of paradoxical growth enhancement by alpha-fetoprotein (AFP), a nonmitogenic factor, was explored in HL-60 cells using novel AFP agonists, the 167H |
| 7532927 | 4 monoclonal antibodies (MAbs) to AFP receptor (AFPr) isoforms |
| 7532927 | The conditions underwhich AFP led to increases in thymidine incorporation were found to promote activation induced cell death (AICD) associated with adherence in 96 well plates |
| 7532927 | Both AFP and the 167H |
| 7532927 | 4 MAb blocked the induction of cell death under these conditions indicating apparent growth enhancement by AFP relates to the abrogation of cell death and not that AFP contains bona fide growth factor-like activity |
| 7532927 | 4 MAb blocked the induction of cell death under these conditions indicating apparent growth enhancement by AFP relates to the abrogation of cell death and not that AFP contains bona fide growth factor-like activity |
| 7532927 | Overall, our findings lend further support to the recent proposals that AFP by binding to AFP receptors may block cellular senescence and that there may be differential expression of AFPr isoforms related to commitment (167H |
| 7532927 | Overall, our findings lend further support to the recent proposals that AFP by binding to AFP receptors may block cellular senescence and that there may be differential expression of AFPr isoforms related to commitment (167H |
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