HCSGD entry for DIO3
1. General information
| Official gene symbol | DIO3 |
|---|---|
| Entrez ID | 1735 |
| Gene full name | deiodinase, iodothyronine, type III |
| Other gene symbols | 5DIII D3 DIOIII TXDI3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004800 | Thyroxine 5'-deiodinase activity | IEA NAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006590 | Thyroid hormone generation | TAS | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0010008 | Endosome membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0033798 | Thyroxine 5-deiodinase activity | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042446 | Hormone biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4420208921 | 0.7767273318 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0251605917 |
| GSE13712_SHEAR | Down | -0.2114665402 |
| GSE13712_STATIC | Down | -0.1752655548 |
| GSE19018 | Down | -0.0852539833 |
| GSE19899_A1 | Down | -0.0145029642 |
| GSE19899_A2 | Down | -0.1339067946 |
| PubMed_21979375_A1 | Up | 0.2347985534 |
| PubMed_21979375_A2 | Down | -0.0397881769 |
| GSE35957 | Down | -0.0564850931 |
| GSE36640 | Up | 0.0750758125 |
| GSE54402 | Up | 0.5018479094 |
| GSE9593 | Down | -0.2077687158 |
| GSE43922 | Up | 0.1315573599 |
| GSE24585 | Up | 0.4593360548 |
| GSE37065 | Down | -0.0286257787 |
| GSE28863_A1 | Down | -0.0449797051 |
| GSE28863_A2 | Up | 0.0727107501 |
| GSE28863_A3 | Up | 0.3146761488 |
| GSE28863_A4 | Up | 0.0795497892 |
| GSE48662 | Down | -0.0030019614 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 18056640 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
