HCSGD entry for DIO2
1. General information
| Official gene symbol | DIO2 |
|---|---|
| Entrez ID | 1734 |
| Gene full name | deiodinase, iodothyronine, type II |
| Other gene symbols | 5DII D2 DIOII SelY TXDI2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001514 | Selenocysteine incorporation | NAS | biological_process |
| GO:0004800 | Thyroxine 5'-deiodinase activity | IDA IEA TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006590 | Thyroid hormone generation | TAS | biological_process |
| GO:0008430 | Selenium binding | IC | molecular_function |
| GO:0016020 | Membrane | IC | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042403 | Thyroid hormone metabolic process | IDA | biological_process |
| GO:0042404 | Thyroid hormone catabolic process | IEA | biological_process |
| GO:0042446 | Hormone biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0019127921 | 0.9309658030 | 0.1165430556 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1382070724 |
| GSE13712_SHEAR | Down | -0.0376682207 |
| GSE13712_STATIC | Up | 0.0519336718 |
| GSE19018 | Down | -1.1000820933 |
| GSE19899_A1 | Up | 0.3461026406 |
| GSE19899_A2 | Up | 1.4234387426 |
| PubMed_21979375_A1 | Up | 3.6339054297 |
| PubMed_21979375_A2 | Up | 2.0050740311 |
| GSE35957 | Down | -0.0267105610 |
| GSE36640 | Up | 1.1990458325 |
| GSE54402 | Up | 3.1554371228 |
| GSE9593 | Down | -0.0357417570 |
| GSE43922 | Up | 1.2141194783 |
| GSE24585 | Up | 0.2192265332 |
| GSE37065 | Up | 0.2160624528 |
| GSE28863_A1 | Up | 0.2539597743 |
| GSE28863_A2 | Down | -0.0791098484 |
| GSE28863_A3 | Up | 0.2200157342 |
| GSE28863_A4 | Down | -0.1935924326 |
| GSE48662 | Up | 0.1749546637 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17627613 | It was found that five genes encoding ESE-3, inhibin betaA, RGS5, SSAT and DIO2 were up-regulated in senescent cells induced by RasV12, H(2)O(2) and telomere shortening, but not in quiescent or actively growing cells, suggesting that these genes serve as molecular markers for various types of cellular senescence |
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