HCSGD entry for DIO1
1. General information
| Official gene symbol | DIO1 |
|---|---|
| Entrez ID | 1733 |
| Gene full name | deiodinase, iodothyronine, type I |
| Other gene symbols | 5DI TXDI1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004800 | Thyroxine 5'-deiodinase activity | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006590 | Thyroid hormone generation | TAS | biological_process |
| GO:0008430 | Selenium binding | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042446 | Hormone biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4511851221 | 0.8866439573 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3883816063 |
| GSE13712_SHEAR | Down | -0.0081146785 |
| GSE13712_STATIC | Up | 0.0569249465 |
| GSE19018 | Down | -0.2133045627 |
| GSE19899_A1 | Up | 0.1598525355 |
| GSE19899_A2 | Down | -0.0377107130 |
| PubMed_21979375_A1 | Up | 0.3981374640 |
| PubMed_21979375_A2 | Down | -0.0182897105 |
| GSE35957 | Up | 0.2426453326 |
| GSE36640 | Up | 0.0285139651 |
| GSE54402 | Up | 0.0062897134 |
| GSE9593 | Up | 0.0339599413 |
| GSE43922 | Up | 0.0155785674 |
| GSE24585 | Down | -0.0257053851 |
| GSE37065 | Down | -0.0539919076 |
| GSE28863_A1 | Down | -0.0585159230 |
| GSE28863_A2 | Up | 0.0597004122 |
| GSE28863_A3 | Up | 0.2046762409 |
| GSE28863_A4 | Up | 0.0546956652 |
| GSE48662 | Down | -0.0175255428 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017647 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
