HCSGD entry for DHCR24
1. General information
| Official gene symbol | DHCR24 |
|---|---|
| Entrez ID | 1718 |
| Gene full name | 24-dehydrocholesterol reductase |
| Other gene symbols | DCE Nbla03646 SELADIN1 seladin-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | NAS TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | IEA IMP ISS NAS TAS | biological_process |
| GO:0006915 | Apoptotic process | NAS | biological_process |
| GO:0006979 | Response to oxidative stress | IEP | biological_process |
| GO:0007050 | Cell cycle arrest | NAS | biological_process |
| GO:0007265 | Ras protein signal transduction | IEA | biological_process |
| GO:0008104 | Protein localization | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0008762 | UDP-N-acetylmuramate dehydrogenase activity | IEA | molecular_function |
| GO:0009725 | Response to hormone | IEA | biological_process |
| GO:0009888 | Tissue development | IMP | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016614 | Oxidoreductase activity, acting on CH-OH group of donors | IEA | molecular_function |
| GO:0016628 | Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | IDA | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030539 | Male genitalia development | IEA | biological_process |
| GO:0031639 | Plasminogen activation | IEA | biological_process |
| GO:0042605 | Peptide antigen binding | IPI | molecular_function |
| GO:0042987 | Amyloid precursor protein catabolic process | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0043588 | Skin development | ISS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050614 | Delta24-sterol reductase activity | IEA | molecular_function |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:1901214 | Regulation of neuron death | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0184646138 | 0.0603373428 | 0.3321989747 | 0.4627445221 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8026304261 |
| GSE13712_SHEAR | Down | -0.6947894773 |
| GSE13712_STATIC | Down | -1.4925207621 |
| GSE19018 | Down | -0.2866490338 |
| GSE19899_A1 | Up | 1.3935969869 |
| GSE19899_A2 | Up | 0.7826000725 |
| PubMed_21979375_A1 | Up | 0.2769130114 |
| PubMed_21979375_A2 | Up | 1.6592215793 |
| GSE35957 | Down | -0.7127930430 |
| GSE36640 | Up | 0.7019587966 |
| GSE54402 | Down | -0.2667945161 |
| GSE9593 | Up | 0.3361938192 |
| GSE43922 | Up | 0.2659168554 |
| GSE24585 | Down | -0.4056668871 |
| GSE37065 | Down | -0.0915824393 |
| GSE28863_A1 | Up | 0.4526916426 |
| GSE28863_A2 | Up | 0.5501517713 |
| GSE28863_A3 | Down | -1.0063544513 |
| GSE28863_A4 | Down | -0.2725825280 |
| GSE48662 | Down | -0.0050639942 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002577 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018869 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020936 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024774 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026872 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030596 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040799 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042102 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048668 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049129 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
