HCSGD entry for DHCR7
1. General information
| Official gene symbol | DHCR7 |
|---|---|
| Entrez ID | 1717 |
| Gene full name | 7-dehydrocholesterol reductase |
| Other gene symbols | SLOS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001568 | Blood vessel development | IEA | biological_process |
| GO:0005640 | Nuclear outer membrane | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | IEA IMP TAS | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016126 | Sterol biosynthetic process | IEA | biological_process |
| GO:0016628 | Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | IEA | molecular_function |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045540 | Regulation of cholesterol biosynthetic process | IEA | biological_process |
| GO:0047598 | 7-dehydrocholesterol reductase activity | IDA IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0138673721 | 0.1694159150 | 0.2937043965 | 0.7962716937 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5330016021 |
| GSE13712_SHEAR | Down | -0.3226562627 |
| GSE13712_STATIC | Up | 0.0778990145 |
| GSE19018 | Up | 0.0531900066 |
| GSE19899_A1 | Up | 0.3662907958 |
| GSE19899_A2 | Up | 2.3113657037 |
| PubMed_21979375_A1 | Up | 0.1708967204 |
| PubMed_21979375_A2 | Up | 2.0682919685 |
| GSE35957 | Up | 0.0848639127 |
| GSE36640 | Up | 1.2141115956 |
| GSE54402 | Down | -0.1364382898 |
| GSE9593 | Up | 0.2666660761 |
| GSE43922 | Up | 0.6885724359 |
| GSE24585 | Down | -0.7531798121 |
| GSE37065 | Up | 0.1790726404 |
| GSE28863_A1 | Down | -0.7874071537 |
| GSE28863_A2 | Up | 0.0690479392 |
| GSE28863_A3 | Down | -0.6627348300 |
| GSE28863_A4 | Down | -0.1167890369 |
| GSE48662 | Down | -0.0738360619 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-425-5p | MIMAT0003393 | MIRT016653 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016982 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025254 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052760 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
