HCSGD entry for TIMM8A
1. General information
| Official gene symbol | TIMM8A |
|---|---|
| Entrez ID | 1678 |
| Gene full name | translocase of inner mitochondrial membrane 8 homolog A (yeast) |
| Other gene symbols | DDP DDP1 DFN1 MTS TIM8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | IDA | cellular_component |
| GO:0006626 | Protein targeting to mitochondrion | TAS | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0072321 | Chaperone-mediated protein transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1961721287 | 0.1698575662 | 0.8576747552 | 0.7974164081 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3207891046 |
| GSE13712_SHEAR | Down | -0.2277471226 |
| GSE13712_STATIC | Up | 0.2582294638 |
| GSE19018 | Down | -0.6848966911 |
| GSE19899_A1 | Down | -0.0619623095 |
| GSE19899_A2 | Up | 0.0473190121 |
| PubMed_21979375_A1 | Up | 0.2751449774 |
| PubMed_21979375_A2 | Up | 0.4547026911 |
| GSE35957 | Down | -0.0657794613 |
| GSE36640 | Down | -0.4131867458 |
| GSE54402 | Up | 0.3731625083 |
| GSE9593 | Down | -0.5152139260 |
| GSE43922 | Up | 0.4470528964 |
| GSE24585 | Down | -0.5442455384 |
| GSE37065 | Down | -0.2962103854 |
| GSE28863_A1 | Up | 0.0587571698 |
| GSE28863_A2 | Up | 0.2810773719 |
| GSE28863_A3 | Up | 0.0463660302 |
| GSE28863_A4 | Up | 0.3821646709 |
| GSE48662 | Down | -0.3995007889 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT000053 | Luciferase reporter assay | Functional MTI | 19734348 |
| hsa-miR-375 | MIMAT0000728 | MIRT000053 | Immunohistochemistry//Luciferase reporter assay//Microarray//Northern blot//qRT-PCR | Functional MTI | 19807270 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020870 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028557 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032388 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23272171 | METHODS: We examined in different human NSCLC cell lines and detected cellular senescence after cisplatin (DDP) treatment in the presence or absence of DEX |
| 23272171 | The in vivo effect of the combination of DEX and DDP was assessed by tumor growth experiments using human lung cancer cell lines growing as xenograft tumors in nude mice |
| 23272171 | RESULTS: Co-treatment with DEX during chemotherapy in NSCLC resulted in increased tumor cell viability and inhibition of TIS compared with DDP treated group |
| 23272171 | DEX also significantly reduced DDP sensitivity in vivo |
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