HCSGD entry for DFFB
1. General information
| Official gene symbol | DFFB |
|---|---|
| Entrez ID | 1677 |
| Gene full name | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) |
| Other gene symbols | CAD CPAN DFF-40 DFF2 DFF40 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004516 | Nicotinate phosphoribosyltransferase activity | IEA | molecular_function |
| GO:0004536 | Deoxyribonuclease activity | IBA IEA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006309 | Apoptotic DNA fragmentation | IDA IEA TAS | biological_process |
| GO:0006915 | Apoptotic process | IEA TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030263 | Apoptotic chromosome condensation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9770050910 | 0.0128787318 | 0.9999902473 | 0.2238464026 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0385371637 |
| GSE13712_SHEAR | Down | -0.2199689112 |
| GSE13712_STATIC | Down | -0.1946082560 |
| GSE19018 | Down | -1.0695146675 |
| GSE19899_A1 | Down | -0.2246162677 |
| GSE19899_A2 | Down | -0.4409574184 |
| PubMed_21979375_A1 | Up | 0.0688201935 |
| PubMed_21979375_A2 | Down | -0.1986037941 |
| GSE35957 | Down | -0.3765474233 |
| GSE36640 | Down | -0.9624745403 |
| GSE54402 | Down | -0.0296966494 |
| GSE9593 | Down | -0.9066718819 |
| GSE43922 | Up | 0.0606087656 |
| GSE24585 | Down | -0.7196524971 |
| GSE37065 | Down | -0.1136941608 |
| GSE28863_A1 | Up | 0.1813379574 |
| GSE28863_A2 | Up | 0.3181879193 |
| GSE28863_A3 | Down | -0.1436214867 |
| GSE28863_A4 | Down | -0.0778345886 |
| GSE48662 | Down | -0.1741639582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002560 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002560 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-421 | MIMAT0003339 | MIRT039441 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
