HCSGD entry for DFFA
1. General information
| Official gene symbol | DFFA |
|---|---|
| Entrez ID | 1676 |
| Gene full name | DNA fragmentation factor, 45kDa, alpha polypeptide |
| Other gene symbols | DFF-45 DFF1 ICAD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005811 | Lipid particle | IBA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006309 | Apoptotic DNA fragmentation | TAS | biological_process |
| GO:0006915 | Apoptotic process | IEA TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0070242 | Thymocyte apoptotic process | IEA | biological_process |
| GO:1900118 | Negative regulation of execution phase of apoptosis | IDA | biological_process |
| GO:1902511 | Negative regulation of apoptotic DNA fragmentation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6905798906 | 0.3471622355 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1756216679 |
| GSE13712_SHEAR | Down | -0.1932758644 |
| GSE13712_STATIC | Up | 0.0387609536 |
| GSE19018 | Down | -0.2821129233 |
| GSE19899_A1 | Up | 0.0608817860 |
| GSE19899_A2 | Up | 0.4648990184 |
| PubMed_21979375_A1 | Down | -0.2694366749 |
| PubMed_21979375_A2 | Up | 0.4254354107 |
| GSE35957 | Down | -0.2323609412 |
| GSE36640 | Down | -0.3039015692 |
| GSE54402 | Up | 0.1214777617 |
| GSE9593 | Down | -0.0729593620 |
| GSE43922 | Up | 0.2268774638 |
| GSE24585 | Down | -0.1514002740 |
| GSE37065 | Down | -0.1204179378 |
| GSE28863_A1 | Down | -0.3101704548 |
| GSE28863_A2 | Down | -0.0413507918 |
| GSE28863_A3 | Down | -0.3031107331 |
| GSE28863_A4 | Down | -0.1687677744 |
| GSE48662 | Up | 0.4066070974 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026094 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052026 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
