HCSGD entry for DES

1. General information

Official gene symbolDES
Entrez ID1674
Gene full namedesmin
Other gene symbolsCSM1 CSM2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005200Structural constituent of cytoskeletonTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005882Intermediate filamentIEAcellular_component
GO:0005916Fascia adherensIEAcellular_component
GO:0006936Muscle contractionTASbiological_process
GO:0007010Cytoskeleton organizationTASbiological_process
GO:0008016Regulation of heart contractionTASbiological_process
GO:0008092Cytoskeletal protein bindingIPImolecular_function
GO:0030018Z discIDAcellular_component
GO:0030049Muscle filament slidingTASbiological_process
GO:0031594Neuromuscular junctionIEAcellular_component
GO:0042383SarcolemmaIEAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39557918390.95567021010.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1262912919
GSE13712_SHEARUp0.0840911068
GSE13712_STATICUp0.0001481208
GSE19018Up0.1567478249
GSE19899_A1Up0.1767572035
GSE19899_A2Up0.0671422571
PubMed_21979375_A1Down-0.2197031339
PubMed_21979375_A2Up0.1435294794
GSE35957Up0.1709297471
GSE36640Down-0.1881869084
GSE54402Down-0.0308339500
GSE9593Up0.1242677296
GSE43922Up0.0583434242
GSE24585Up0.1358396691
GSE37065Down-0.0838810707
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.3265592071

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25248920In this context, Jhd2 regulates rDNA recombination through the Tof2/Csm1/Lrs4 pathway and prevents excessive recruitment of Tof2, Csm1/Lrs4 and condensin subunits to the replication fork barrier (RFB) site within the NTS1 region
25248920CONCLUSIONS: Our results show that yeast Jhd2, which demethylates histone H3 Lys4 near the rDNA locus, regulates rDNA repeat stability and rDNA silencing in a Sir2-independent manner by maintaining Csm1/Lrs4 and condensin association with rDNA regions during mitosis
25248920These data suggest that Jhd2-mediated alleviation of excessive Csm1/Lrs4 or condensin at the NTS1 region of rDNA is required for the integrity of rDNA repeats and proper rDNA silencing during mitosis
23374245Cultures that maintained their initial proportion of myogenic cells (desmin positive) with passaging (n = 5) were studied and compared with cells from the same individuals in the non-senescent state
19520256BACKGROUND: Endothelial cell senescence may play a role in impaired re-endothelialization after drug-eluting stent (DES) implantation
19520256These results may have therapeutic implications in the clinical sequelae after DES implantation
7963113RESULTS: In the stenotic valves nearly all interstitial cells expressed vimentin, and approximately 60% of the cells also expressed alpha-actin and desmin
7963113In control valves, fibroblasts expressed vimentin but not alpha-actin or desmin
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