HCSGD entry for AES

1. General information

Official gene symbolAES
Entrez ID166
Gene full nameamino-terminal enhancer of split
Other gene symbolsAES-1 AES-2 ESP1 GRG GRG5 TLE5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0001501Skeletal system developmentIEAbiological_process
GO:0003714Transcription corepressor activityIDA IEA IPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0010629Negative regulation of gene expressionIMPbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0031668Cellular response to extracellular stimulusIEAbiological_process
GO:0032091Negative regulation of protein bindingIDAbiological_process
GO:0040008Regulation of growthIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0060761Negative regulation of response to cytokine stimulusIMPbiological_process
GO:0070555Response to interleukin-1IDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:2000210Positive regulation of anoikisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34437104590.13638480300.99999024730.7116242220

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0374827166
GSE13712_SHEARUp0.1789050228
GSE13712_STATICDown-0.0953867078
GSE19018Up0.2116464192
GSE19899_A1Down-0.7728226799
GSE19899_A2Up0.7395921074
PubMed_21979375_A1Up0.2380963179
PubMed_21979375_A2Up0.6145307671
GSE35957Down-0.0642931980
GSE36640Up0.0318725227
GSE54402Down-0.5202438252
GSE9593Up0.1748769691
GSE43922Down-0.1364417032
GSE24585Down-0.3213632630
GSE37065Down-0.0022910761
GSE28863_A1Down-0.1185172738
GSE28863_A2Down-0.1310564022
GSE28863_A3Down-0.2128223473
GSE28863_A4Up0.0506938728
GSE48662Up0.1929788189

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.