HCSGD entry for DHX8
1. General information
| Official gene symbol | DHX8 |
|---|---|
| Entrez ID | 1659 |
| Gene full name | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
| Other gene symbols | DDX8 HRH1 PRP22 PRPF22 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000398 | MRNA splicing, via spliceosome | IC | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005681 | Spliceosomal complex | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0071013 | Catalytic step 2 spliceosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3220552677 | 0.7851537518 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1375745630 |
| GSE13712_SHEAR | Down | -0.3764959718 |
| GSE13712_STATIC | Down | -0.2591475964 |
| GSE19018 | Down | -0.1660172047 |
| GSE19899_A1 | Down | -0.0085339559 |
| GSE19899_A2 | Up | 0.0353184995 |
| PubMed_21979375_A1 | Down | -0.3138568040 |
| PubMed_21979375_A2 | Up | 0.7446757904 |
| GSE35957 | Up | 0.0908803799 |
| GSE36640 | Down | -0.2839377149 |
| GSE54402 | Up | 0.0348698106 |
| GSE9593 | Up | 0.0540860839 |
| GSE43922 | Up | 0.0015097345 |
| GSE24585 | Up | 0.3193869747 |
| GSE37065 | Up | 0.0546009139 |
| GSE28863_A1 | Up | 0.7035842090 |
| GSE28863_A2 | Up | 0.3745895946 |
| GSE28863_A3 | Down | -0.0627397989 |
| GSE28863_A4 | Up | 0.0653112822 |
| GSE48662 | Down | -0.0270261606 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028503 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031619 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1180-3p | MIMAT0005825 | MIRT035945 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-935 | MIMAT0004978 | MIRT036658 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043497 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047917 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049306 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
