HCSGD entry for DDIT3

1. General information

Official gene symbolDDIT3
Entrez ID1649
Gene full nameDNA-damage-inducible transcript 3
Other gene symbolsCEBPZ CHOP CHOP-10 CHOP10 GADD153
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001955Blood vessel maturationIEAbiological_process
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005770Late endosomeIEAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIMPbiological_process
GO:0006974Cellular response to DNA damage stimulusTASbiological_process
GO:0006983ER overload responseIEAbiological_process
GO:0006986Response to unfolded proteinIDAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseIEA TASbiological_process
GO:0032757Positive regulation of interleukin-8 productionIMPbiological_process
GO:0034976Response to endoplasmic reticulum stressIDAbiological_process
GO:0042594Response to starvationIEAbiological_process
GO:0042789MRNA transcription from RNA polymerase II promoterIDAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0043620Regulation of DNA-templated transcription in response to stressTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044324Regulation of transcription involved in anterior/posterior axis specificationIEA ISSbiological_process
GO:0045454Cell redox homeostasisIDAbiological_process
GO:0045662Negative regulation of myoblast differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIEAbiological_process
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIDA IEA IMPbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEA ISSbiological_process
GO:2000016Negative regulation of determination of dorsal identityIDA IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00223860420.97161306940.12701875001.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.3898314092
GSE13712_SHEARUp0.7301966670
GSE13712_STATICDown-0.0823436190
GSE19018Up0.0313299414
GSE19899_A1Up0.5947281311
GSE19899_A2Up0.3530941845
PubMed_21979375_A1Up1.4151110289
PubMed_21979375_A2Up0.3033094483
GSE35957Down-0.6470989566
GSE36640Up0.8867762643
GSE54402Up0.0639740670
GSE9593Up1.3264928791
GSE43922Up0.4061640954
GSE24585Up0.7230825756
GSE37065Down-0.0131819677
GSE28863_A1Up0.2057630172
GSE28863_A2Up0.5929602971
GSE28863_A3Up0.0071297942
GSE28863_A4Down-0.0034994964
GSE48662Up0.2017114619

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016927MicroarrayFunctional MTI (Weak)18185580
hsa-miR-96-5pMIMAT0000095MIRT027903SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25149687However, H2O2-SIPS does not exhibit IRE1 and ATF6 pathways activation but a PERK-mediated upregulation of CCAAT/enhancer-binding protein homologous protein, showing that CuSO4-SIPS mimics better the endoplasmic reticulum molecular events of replicative senescence than H2O2-SIPS
23514618Gene array qPCR analysis of MIA PaCa-2 cells treated with the lead compound revealed significant dose-dependent modulation of a distinct subset of genes, including strong induction of DNA damage responsive genes CDKN1A, DDIT3, GADD45A/G, and PPM1D, and repression of genes involved in telomere maintenance, including hPOT1 and PARP1
22788682ER stress was detected by assays for glucose-regulated protein 78 (GRP78), CCAAT/enhancer-binding protein homologous protein (CHOP), and growth arrest and DNA damage-inducible protein 34 (GADD34) mRNA, and transient phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha)
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