HCSGD entry for AKR1C1

1. General information

Official gene symbolAKR1C1
Entrez ID1645
Gene full namealdo-keto reductase family 1, member C1
Other gene symbols2-ALPHA-HSD 20-ALPHA-HSD C9 DD1 DD1/DD2 DDH DDH1 H-37 HAKRC HBAB MBAB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0004032Alditol:NADP+ 1-oxidoreductase activityIDAmolecular_function
GO:0004033Aldo-keto reductase (NADP) activityTASmolecular_function
GO:0005829CytosolIDA TAScellular_component
GO:0006805Xenobiotic metabolic processNASbiological_process
GO:0007586DigestionIDAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008206Bile acid metabolic processIDAbiological_process
GO:0015721Bile acid and bile salt transportTASbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0016655Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorIDAmolecular_function
GO:0018636Phenanthrene 9,10-monooxygenase activityIDAmolecular_function
GO:0030299Intestinal cholesterol absorptionTASbiological_process
GO:0031406Carboxylic acid bindingIDAmolecular_function
GO:0032052Bile acid bindingIDAmolecular_function
GO:0042448Progesterone metabolic processIDAbiological_process
GO:0042574Retinal metabolic processIDAbiological_process
GO:0042632Cholesterol homeostasisTASbiological_process
GO:0044597Daunorubicin metabolic processIMPbiological_process
GO:0044598Doxorubicin metabolic processIMPbiological_process
GO:0046683Response to organophosphorusIEPbiological_process
GO:004700617-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activityIEAmolecular_function
GO:0047042Androsterone dehydrogenase (B-specific) activityIDAmolecular_function
GO:0047086Ketosteroid monooxygenase activityIDAmolecular_function
GO:0047115Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityIDAmolecular_function
GO:0047718Indanol dehydrogenase activityIEAmolecular_function
GO:0051260Protein homooligomerizationIDAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0071395Cellular response to jasmonic acid stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00518229170.51194708030.18788305791.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.5637452428
GSE13712_SHEARDown-0.6089321773
GSE13712_STATICDown-0.3608661754
GSE19018Down-0.6348809229
GSE19899_A1Down-0.1458953366
GSE19899_A2Down-1.2850849058
PubMed_21979375_A1Up0.5800313911
PubMed_21979375_A2Down-0.2324108990
GSE35957Down-0.1483842496
GSE36640Up0.9163961309
GSE54402Up0.2202573967
GSE9593Up0.2479133157
GSE43922Up0.2360331483
GSE24585Up1.0382647410
GSE37065Up0.6421267795
GSE28863_A1Up0.5326487409
GSE28863_A2Up1.4743714690
GSE28863_A3Up0.1743728060
GSE28863_A4Up0.3399772161
GSE48662Up0.3739765488

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
Salicylic acidDB00936 APRD01605 | DB01398
2'-Monophosphoadenosine 5'-DiphosphoriboseDB03461 EXPT02293
2-HYDROXY-3,5-DIIODOBENZOIC ACIDDB04674 -
(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONEDB07768 -
HexestrolDB07931 DB08959

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.