HCSGD entry for DDB2
1. General information
| Official gene symbol | DDB2 |
|---|---|
| Entrez ID | 1643 |
| Gene full name | damage-specific DNA binding protein 2, 48kDa |
| Other gene symbols | DDBB UV-DDB2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0000718 | Nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003684 | Damaged DNA binding | TAS | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | TAS | biological_process |
| GO:0006290 | Pyrimidine dimer repair | IEA | biological_process |
| GO:0009411 | Response to UV | IDA | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0051865 | Protein autoubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0040327115 | 0.9597422552 | 0.1712016129 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5928817539 |
| GSE13712_SHEAR | Up | 0.0587253274 |
| GSE13712_STATIC | Up | 0.2094195886 |
| GSE19018 | Up | 1.1561834536 |
| GSE19899_A1 | Up | 0.6833082135 |
| GSE19899_A2 | Up | 0.5396086942 |
| PubMed_21979375_A1 | Up | 0.4510981564 |
| PubMed_21979375_A2 | Up | 0.6632909015 |
| GSE35957 | Down | -0.4914430490 |
| GSE36640 | Down | -0.1416610737 |
| GSE54402 | Down | -0.5075372289 |
| GSE9593 | Down | -0.0000811713 |
| GSE43922 | Up | 0.4416430151 |
| GSE24585 | Up | 0.8456250154 |
| GSE37065 | Up | 0.2134398497 |
| GSE28863_A1 | Up | 0.1733137321 |
| GSE28863_A2 | Down | -0.0314064150 |
| GSE28863_A3 | Down | -0.3479102819 |
| GSE28863_A4 | Up | 0.3583899445 |
| GSE48662 | Up | 0.6486449611 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020865 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029978 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22705887 | To investigate the implications for human vascular disease, we explored associations between single-nucleotide polymorphisms of selected nucleotide excision repair genes and arterial stiffness within the AortaGen Consortium and found a significant association of a single-nucleotide polymorphism (rs2029298) in the putative promoter region of DDB2 gene with carotid-femoral pulse wave velocity |
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