HCSGD entry for DDB1
1. General information
| Official gene symbol | DDB1 |
|---|---|
| Entrez ID | 1642 |
| Gene full name | damage-specific DNA binding protein 1, 127kDa |
| Other gene symbols | DDBA UV-DDB1 XAP1 XPCE XPE XPE-BF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000718 | Nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003684 | Damaged DNA binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0031464 | Cul4A-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0031465 | Cul4B-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0080008 | Cul4-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:1901990 | Regulation of mitotic cell cycle phase transition | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0742936287 | 0.8912585654 | 0.5786908930 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3464596323 |
| GSE13712_SHEAR | Down | -0.0806850338 |
| GSE13712_STATIC | Down | -0.0338892007 |
| GSE19018 | Up | 0.5496582566 |
| GSE19899_A1 | Down | -0.2087577461 |
| GSE19899_A2 | Up | 0.0693213435 |
| PubMed_21979375_A1 | Up | 0.0760635711 |
| PubMed_21979375_A2 | Up | 0.4919744371 |
| GSE35957 | Up | 0.5667506721 |
| GSE36640 | Up | 0.0623746702 |
| GSE54402 | Up | 0.1266483481 |
| GSE9593 | Up | 0.0185491229 |
| GSE43922 | Up | 0.0004816545 |
| GSE24585 | Up | 0.1190140172 |
| GSE37065 | Down | -0.4498533604 |
| GSE28863_A1 | Up | 0.5879767046 |
| GSE28863_A2 | Up | 0.5608756694 |
| GSE28863_A3 | Down | -0.1488811264 |
| GSE28863_A4 | Up | 0.0437022393 |
| GSE48662 | Up | 0.0833572031 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016411 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-941 | MIMAT0004984 | MIRT036583 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045270 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045485 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047942 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050184 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3200-3p | MIMAT0015085 | MIRT052820 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19208841 | We further show that damaged DNA binding protein DDB1 and CUL4, which assemble distinct E3 ubiquitin ligases by recruiting various WD40 proteins, act upstream of MLL1-mediated H3K4 methylation |
| 19208841 | We showed that CUL4A directly binds to p16 and that silencing DDB1 blocks Ras-induced p16 activation |
| 16002407 | The purification of this complex showed that it contains the damage-specific DNA-binding protein DDB-1 |
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