HCSGD entry for DCN
1. General information
| Official gene symbol | DCN |
|---|---|
| Entrez ID | 1634 |
| Gene full name | decorin |
| Other gene symbols | CSCD DSPG2 PG40 PGII PGS2 SLRR1B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0001890 | Placenta development | IEA | biological_process |
| GO:0005518 | Collagen binding | IEA | molecular_function |
| GO:0005539 | Glycosaminoglycan binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005589 | Collagen type VI | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0007519 | Skeletal muscle tissue development | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0009612 | Response to mechanical stimulus | IEA | biological_process |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0019800 | Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0030204 | Chondroitin sulfate metabolic process | TAS | biological_process |
| GO:0030206 | Chondroitin sulfate biosynthetic process | TAS | biological_process |
| GO:0030207 | Chondroitin sulfate catabolic process | TAS | biological_process |
| GO:0030208 | Dermatan sulfate biosynthetic process | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA ISS | cellular_component |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0042060 | Wound healing | IEA | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047485 | Protein N-terminus binding | IEA | molecular_function |
| GO:0050840 | Extracellular matrix binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0438054785 | 0.0010662247 | 0.4662210994 | 0.0622263858 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6887740859 |
| GSE13712_SHEAR | Down | -0.1058393660 |
| GSE13712_STATIC | Down | -0.2603734851 |
| GSE19018 | Down | -1.3404480940 |
| GSE19899_A1 | Down | -2.0337088565 |
| GSE19899_A2 | Down | -2.7615716501 |
| PubMed_21979375_A1 | Down | -3.7722945201 |
| PubMed_21979375_A2 | Down | -3.9250153496 |
| GSE35957 | Up | 0.3455067966 |
| GSE36640 | Down | -0.3796537373 |
| GSE54402 | Down | -1.6805910730 |
| GSE9593 | Up | 0.5205835436 |
| GSE43922 | Down | -2.8436134587 |
| GSE24585 | Up | 0.0253804944 |
| GSE37065 | Up | 0.3842251667 |
| GSE28863_A1 | Up | 1.4030333529 |
| GSE28863_A2 | Up | 1.8699727794 |
| GSE28863_A3 | Down | -0.1470899578 |
| GSE28863_A4 | Up | 0.4383867939 |
| GSE48662 | Up | 0.2492943696 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Tris | DB03754 | EXPT03072 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18830193 | Immunohistochemical study of decorin expression in polyps and carcinomas of the colon |
| 18830193 | BACKGROUND: Recent studies showed that a small leucine-rich proteoglycan, decorin, may suppress tumor progression as a natural anticancer agent negatively controlling cellular growth |
| 18830193 | It was hypothesized that physiological expression of decorin may be associated with cellular senescence of the colorectal mucosa and that its down-regulation, promoting an increase in cellular proliferation, could participate in the progression of adenoma to adenocarcinoma |
| 18830193 | Therefore the expression of decorin in hyperplastic and neoplastic polyps of the colorectum was examined and compared with normal colonic mucosa and colon cancer tissues |
| 18830193 | RESULTS: Normal and hyperplastic tissues and the majority of tubular adenomas showed strong expression of decorin in the stroma |
| 18830193 | Adenomas with a villous component showed moderate and very low decorin immunoreactivity |
| 18830193 | The decrease in decorin reactivity in tubulo-villous adenomas was significant as compared with other polyps and controls |
| 18830193 | Weak decorin immunoreactivity in stroma adjacent to clusters of cancerous cells was also found in most cases of common types of adenocarcinoma, but not in adenocarcinoma mucinosum |
| 18830193 | CONCLUSIONS: The expression of decorin may be involved in the differentiation of colonic polyps and reduced expression of decorin may abrogate the defensive potential of stromal tissue and promote the development of common types of colon carcinoma |
| 11344338 | The MK/T-1 cells express vimentin, tubulin, lumican, mimecan, decorin and collagen I, but not keratocan |
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