HCSGD entry for DCC

1. General information

Official gene symbolDCC
Entrez ID1630
Gene full namedeleted in colorectal carcinoma
Other gene symbolsCRC18 CRCR1 IGDCC1 MRMV1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001764Neuron migrationIEAbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:0003713Transcription coactivator activityIEAmolecular_function
GO:0004888Transmembrane signaling receptor activityTASmolecular_function
GO:0005042Netrin receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0007409AxonogenesisTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0010976Positive regulation of neuron projection developmentIEAbiological_process
GO:0010977Negative regulation of neuron projection developmentTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0021965Spinal cord ventral commissure morphogenesisIEAbiological_process
GO:0030424AxonIEAcellular_component
GO:0032584Growth cone membraneIEAcellular_component
GO:0033563Dorsal/ventral axon guidanceIEAbiological_process
GO:0033564Anterior/posterior axon guidanceIEAbiological_process
GO:0042802Identical protein bindingIEAmolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0048671Negative regulation of collateral sproutingTASbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:2000171Negative regulation of dendrite developmentTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04839405800.95046237230.48642702091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0290235562
GSE13712_SHEARUp0.0699010665
GSE13712_STATICDown-0.0062263597
GSE19018Up0.0039903245
GSE19899_A1Up0.1382365343
GSE19899_A2Up0.5391224490
PubMed_21979375_A1Up0.4791386556
PubMed_21979375_A2Up0.4273263578
GSE35957Up0.0503429966
GSE36640Down-0.2045259001
GSE54402Up2.4377113647
GSE9593Down-0.0460555235
GSE43922Up2.4723271421
GSE24585Down-0.0570797106
GSE37065Down-0.0575545569
GSE28863_A1Down-0.0556595799
GSE28863_A2Down-0.0630351853
GSE28863_A3Up0.1820597550
GSE28863_A4Down-0.0332409319
GSE48662Up0.0047657189

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022668MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.