HCSGD entry for SPPL2C
1. General information
| Official gene symbol | SPPL2C |
|---|---|
| Entrez ID | 162540 |
| Gene full name | signal peptide peptidase like 2C |
| Other gene symbols | IMP5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004190 | Aspartic-type endopeptidase activity | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0006509 | Membrane protein ectodomain proteolysis | IMP | biological_process |
| GO:0031293 | Membrane protein intracellular domain proteolysis | IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0071458 | Integral component of cytoplasmic side of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0071556 | Integral component of lumenal side of endoplasmic reticulum membrane | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5614614870 | 0.8144721325 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | 0.0000000000 |
| GSE13712_SHEAR | Up | 0.0230667732 |
| GSE13712_STATIC | Down | -0.0113482004 |
| GSE19018 | Up | 0.0210879947 |
| GSE19899_A1 | Up | 0.0675548687 |
| GSE19899_A2 | Down | -0.0920275698 |
| PubMed_21979375_A1 | Down | -0.0006613667 |
| PubMed_21979375_A2 | Up | 0.0546799029 |
| GSE35957 | Down | -0.0824956994 |
| GSE36640 | Down | -0.0050368529 |
| GSE54402 | Up | 0.0832726097 |
| GSE9593 | Up | 0.0654275391 |
| GSE43922 | Up | 0.0239041694 |
| GSE24585 | Up | 0.1060214397 |
| GSE37065 | Down | -0.0956947639 |
| GSE28863_A1 | Down | -0.0698434537 |
| GSE28863_A2 | Down | -0.1106521208 |
| GSE28863_A3 | Up | 0.4161837203 |
| GSE28863_A4 | Up | 0.1637952245 |
| GSE48662 | Up | 0.0458502065 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017486 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
