HCSGD entry for DAXX
1. General information
| Official gene symbol | DAXX |
|---|---|
| Entrez ID | 1616 |
| Gene full name | death-domain associated protein |
| Other gene symbols | BING2 DAP6 EAP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000281 | Mitotic cytokinesis | IEA | biological_process |
| GO:0000775 | Chromosome, centromeric region | IEA | cellular_component |
| GO:0000792 | Heterochromatin | IEA | cellular_component |
| GO:0002039 | P53 binding | IPI | molecular_function |
| GO:0005057 | Receptor signaling protein activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IMP | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | ISS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007257 | Activation of JUN kinase activity | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IDA | molecular_function |
| GO:0008625 | Extrinsic apoptotic signaling pathway via death domain receptors | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016605 | PML body | IDA IEA TAS | cellular_component |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030521 | Androgen receptor signaling pathway | IDA | biological_process |
| GO:0031072 | Heat shock protein binding | TAS | molecular_function |
| GO:0031396 | Regulation of protein ubiquitination | IDA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA IEA | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0050681 | Androgen receptor binding | IPI | molecular_function |
| GO:0097190 | Apoptotic signaling pathway | IEA | biological_process |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1182894571 | 0.3622587364 | 0.7056883046 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3277696998 |
| GSE13712_SHEAR | Down | -0.1651530664 |
| GSE13712_STATIC | Up | 0.0873925364 |
| GSE19018 | Down | -0.3350415961 |
| GSE19899_A1 | Up | 0.1711755322 |
| GSE19899_A2 | Up | 0.7807500045 |
| PubMed_21979375_A1 | Up | 0.8214421802 |
| PubMed_21979375_A2 | Up | 0.5939822035 |
| GSE35957 | Down | -1.0568997171 |
| GSE36640 | Down | -0.8363570054 |
| GSE54402 | Down | -0.1584377312 |
| GSE9593 | Down | -0.0571734892 |
| GSE43922 | Up | 0.0517500338 |
| GSE24585 | Down | -0.5913355173 |
| GSE37065 | Up | 0.1813151314 |
| GSE28863_A1 | Up | 0.3747963603 |
| GSE28863_A2 | Up | 0.2413678995 |
| GSE28863_A3 | Up | 0.3588106046 |
| GSE28863_A4 | Up | 0.0286628476 |
| GSE48662 | Up | 0.0125226925 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT005327 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18829576 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046750 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24200965 | We further show that overexpression of DAXX enhances targeting of H3 |
| 24200965 | 3 from pericentromeric heterochromatin upon DAXX or PML depletion suggests that the targeting of H3 |
| 21198351 | PML is the organizer of the NBs that contains at least 2 permanent NB-associated proteins, the IFN-stimulated gene product Speckled protein of 100 kDa (Sp100) and death-associated dead protein (Daxx), as well as numerous other transient proteins recruited in these structures in response to different stimuli |
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