HCSGD entry for DAPK1

1. General information

Official gene symbolDAPK1
Entrez ID1612
Gene full namedeath-associated protein kinase 1
Other gene symbolsDAPK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEA TASmolecular_function
GO:0004683Calmodulin-dependent protein kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIDAmolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0006468Protein phosphorylationIDA TASbiological_process
GO:0006915Apoptotic processIGI IMP TASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:0010506Regulation of autophagyTASbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0017148Negative regulation of translationIDAbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0046777Protein autophosphorylationIDA TASbiological_process
GO:0071346Cellular response to interferon-gammaIDAbiological_process
GO:0097190Apoptotic signaling pathwayIMPbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:2000310Regulation of N-methyl-D-aspartate selective glutamate receptor activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35558446490.10768753470.99999024730.6279048283

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1735150145
GSE13712_SHEARUp0.1260738982
GSE13712_STATICDown-0.6871826531
GSE19018Down-0.3929767546
GSE19899_A1Up0.3077057678
GSE19899_A2Up0.0692544390
PubMed_21979375_A1Down-0.1820417247
PubMed_21979375_A2Up0.1305683229
GSE35957Down-0.3883857656
GSE36640Down-0.0917694725
GSE54402Up0.0968982888
GSE9593Up0.3761557688
GSE43922Up0.0150353435
GSE24585Down-0.2229745513
GSE37065Down-0.4011031991
GSE28863_A1Down-0.3826771485
GSE28863_A2Up0.0362287705
GSE28863_A3Up0.2101030040
GSE28863_A4Up0.2320217521
GSE48662Up0.0893754999

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5,6-Dihydro-Benzo[H]Cinnolin-3-YlamineDB04069 EXPT01270
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524
6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONEDB07444 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-214-3pMIMAT0000271MIRT004738Microarray//qRT-PCRFunctional MTI (Weak)19435428
hsa-miR-103a-3pMIMAT0000101MIRT006690Luciferase reporter assay//Western blotFunctional MTI22593189
hsa-miR-107MIMAT0000104MIRT006691Luciferase reporter assay//Western blotFunctional MTI22593189
hsa-miR-124-3pMIMAT0000422MIRT022627MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.