HCSGD entry for CD55
1. General information
| Official gene symbol | CD55 |
|---|---|
| Entrez ID | 1604 |
| Gene full name | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| Other gene symbols | CR CROM DAF TC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001618 | Virus receptor activity | IEA | molecular_function |
| GO:0004857 | Enzyme inhibitor activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006958 | Complement activation, classical pathway | IEA | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | IDA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0030449 | Regulation of complement activation | TAS | biological_process |
| GO:0031225 | Anchored component of membrane | IEA | cellular_component |
| GO:0043434 | Response to peptide hormone | IEA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045121 | Membrane raft | IDA | cellular_component |
| GO:0045730 | Respiratory burst | NAS | biological_process |
| GO:0045916 | Negative regulation of complement activation | IEA | biological_process |
| GO:0060137 | Maternal process involved in parturition | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0028838228 | 0.9630764599 | 0.1443062738 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1662214596 |
| GSE13712_SHEAR | Up | 0.6692741892 |
| GSE13712_STATIC | Up | 0.6234711512 |
| GSE19018 | Up | 0.3353658308 |
| GSE19899_A1 | Up | 0.7931827958 |
| GSE19899_A2 | Up | 0.0163610501 |
| PubMed_21979375_A1 | Up | 1.9383204572 |
| PubMed_21979375_A2 | Up | 0.9403526154 |
| GSE35957 | Up | 1.3303952472 |
| GSE36640 | Up | 0.7808093627 |
| GSE54402 | Up | 0.0340034351 |
| GSE9593 | Up | 0.8244016096 |
| GSE43922 | Up | 0.3690794640 |
| GSE24585 | Up | 0.2089888600 |
| GSE37065 | Up | 0.7525849851 |
| GSE28863_A1 | Down | -0.3683420855 |
| GSE28863_A2 | Up | 0.5290098401 |
| GSE28863_A3 | Down | -0.0760799174 |
| GSE28863_A4 | Down | -0.2233148068 |
| GSE48662 | Down | -0.1324147264 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-132-3p | MIMAT0000426 | MIRT021757 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022237 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031474 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052481 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22206234 | Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia |
| 22206234 | METHODS: A cross sectional study was conducted in the north-east coast of Tanzania to investigate whether the changes in glycosylphosphatidylinositol (GPI)-anchored complement regulatory proteins (CD55 and CD59) contributes to malaria anaemia |
| 22206234 | Levels of CD55 and CD59 were measured by flow cytometer and compared between anaemic (8 |
| 22206234 | RESULTS: Levels of CD55 and CD59 decreased with increased RBC age |
| 22206234 | CD55 levels were lower in anaemic children and the difference was seen in RBC of all ages |
| 22206234 | CD55, but not CD59, levels correlated positively with the level of haemoglobin in anaemic children |
| 22206234 | CONCLUSION: The extent of CD55 loss from RBC of all ages early in the course of malarial anaemia and the correlation of CD55 with haemoglobin levels support the hypothesis that CD55 may play a causal role in this disorder |
| 17951672 | Surface markers that can be used to characterize FLS include positive staining for VCAM-1, CD44, CD55, CD90 (Thy-1), and cadherin-11, coupled with the absence of macrophage markers such as CD14 or CD68 |
| 17188915 | RBC membrane molecules CD55 and CD59 along with phosphatydylserine and CD47 were measured |
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