HCSGD entry for AP2A1
1. General information
| Official gene symbol | AP2A1 |
|---|---|
| Entrez ID | 160 |
| Gene full name | adaptor-related protein complex 2, alpha 1 subunit |
| Other gene symbols | ADTAA AP2-ALPHA CLAPA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006886 | Intracellular protein transport | NAS | biological_process |
| GO:0006895 | Golgi to endosome transport | NAS | biological_process |
| GO:0006897 | Endocytosis | NAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IEA | molecular_function |
| GO:0008565 | Protein transporter activity | IEA | molecular_function |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016323 | Basolateral plasma membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0030122 | AP-2 adaptor complex | NAS | cellular_component |
| GO:0030130 | Clathrin coat of trans-Golgi network vesicle | NAS | cellular_component |
| GO:0030666 | Endocytic vesicle membrane | TAS | cellular_component |
| GO:0042059 | Negative regulation of epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0050690 | Regulation of defense response to virus by virus | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1361008016 | 0.8559029140 | 0.7444532835 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1311952944 |
| GSE13712_SHEAR | Up | 0.0647474893 |
| GSE13712_STATIC | Down | -0.0573306596 |
| GSE19018 | Up | 0.1372512533 |
| GSE19899_A1 | Down | -0.0894460354 |
| GSE19899_A2 | Up | 0.4225186794 |
| PubMed_21979375_A1 | Down | -0.3314695417 |
| PubMed_21979375_A2 | Up | 0.4628702137 |
| GSE35957 | Up | 0.2401834349 |
| GSE36640 | Up | 0.1367622426 |
| GSE54402 | Up | 0.1398471404 |
| GSE9593 | Up | 0.1698913977 |
| GSE43922 | Down | -0.0979258934 |
| GSE24585 | Up | 0.0334418474 |
| GSE37065 | Down | -0.1601359140 |
| GSE28863_A1 | Up | 0.6252089369 |
| GSE28863_A2 | Up | 0.3084864036 |
| GSE28863_A3 | Down | -0.2536411201 |
| GSE28863_A4 | Down | -0.0215898096 |
| GSE48662 | Up | 0.3085913315 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005209 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT023447 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025297 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027091 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031661 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031661 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042848 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046880 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
