HCSGD entry for CYP17A1

1. General information

Official gene symbolCYP17A1
Entrez ID1586
Gene full namecytochrome P450, family 17, subfamily A, polypeptide 1
Other gene symbolsCPT7 CYP17 P450C17 S17AH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004508Steroid 17-alpha-monooxygenase activityIDAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005783Endoplasmic reticulumNAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006694Steroid biosynthetic processTASbiological_process
GO:0006702Androgen biosynthetic processTASbiological_process
GO:0006704Glucocorticoid biosynthetic processTASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0007548Sex differentiationTASbiological_process
GO:0008202Steroid metabolic processIDA TASbiological_process
GO:0009635Response to herbicideIEAbiological_process
GO:0010034Response to acetateIEAbiological_process
GO:0010212Response to ionizing radiationIEAbiological_process
GO:0016125Sterol metabolic processTASbiological_process
GO:0017085Response to insecticideIEAbiological_process
GO:0018879Biphenyl metabolic processIEAbiological_process
GO:0018894Dibenzo-p-dioxin metabolic processIEAbiological_process
GO:0018958Phenol-containing compound metabolic processIEAbiological_process
GO:0018963Phthalate metabolic processIEAbiological_process
GO:0019825Oxygen bindingTASmolecular_function
GO:0020037Heme bindingIDAmolecular_function
GO:0021766Hippocampus developmentIEAbiological_process
GO:0030325Adrenal gland developmentIEAbiological_process
GO:0030424AxonIEAcellular_component
GO:0030728OvulationIEAbiological_process
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0033327Leydig cell differentiationIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0042446Hormone biosynthetic processIDAbiological_process
GO:0042448Progesterone metabolic processIDAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:004744217-alpha-hydroxyprogesterone aldolase activityIEAmolecular_function
GO:0048545Response to steroid hormoneIEAbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0051597Response to methylmercuryIEAbiological_process
GO:0060992Response to fungicideIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071236Cellular response to antibioticIEAbiological_process
GO:0071371Cellular response to gonadotropin stimulusIEAbiological_process
GO:0090031Positive regulation of steroid hormone biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48875345160.81383524560.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0608569617
GSE13712_SHEARUp0.0601688182
GSE13712_STATICDown-0.0159865894
GSE19018Down-0.0987685484
GSE19899_A1Up0.0724549160
GSE19899_A2Up0.0876755742
PubMed_21979375_A1Down-0.2040163402
PubMed_21979375_A2Up0.0152359291
GSE35957Up0.1297380434
GSE36640Up0.0247033649
GSE54402Down-0.0218406276
GSE9593Up0.0188784538
GSE43922Up0.0242093859
GSE24585Down-0.1827772420
GSE37065Up0.0056564504
GSE28863_A1Down-0.0894666840
GSE28863_A2Up0.0191472422
GSE28863_A3Up0.2825545486
GSE28863_A4Up0.0811975366
GSE48662Up0.7902225367

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
AbirateroneDB05812 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.