HCSGD entry for CYP11B1

1. General information

Official gene symbolCYP11B1
Entrez ID1584
Gene full namecytochrome P450, family 11, subfamily B, polypeptide 1
Other gene symbolsCPN1 CYP11B FHI P450C11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004497Monooxygenase activityIEAmolecular_function
GO:0004507Steroid 11-beta-monooxygenase activityIDA IMPmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIC TAScellular_component
GO:0006700C21-steroid hormone biosynthetic processIDAbiological_process
GO:0006704Glucocorticoid biosynthetic processTASbiological_process
GO:0006705Mineralocorticoid biosynthetic processTASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0006955Immune responseTASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008217Regulation of blood pressureIMPbiological_process
GO:0016125Sterol metabolic processTASbiological_process
GO:0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEAmolecular_function
GO:0020037Heme bindingIC IEAmolecular_function
GO:0032342Aldosterone biosynthetic processIDA IMPbiological_process
GO:0032870Cellular response to hormone stimulusIEPbiological_process
GO:0034651Cortisol biosynthetic processIDA IMPbiological_process
GO:0035865Cellular response to potassium ionIEPbiological_process
GO:0042593Glucose homeostasisTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48026907790.92278633790.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0775015382
GSE13712_SHEARUp0.0703922052
GSE13712_STATICDown-0.1729251803
GSE19018Up0.2178534264
GSE19899_A1Up0.1512226142
GSE19899_A2Up0.1545087619
PubMed_21979375_A1Up0.1677538562
PubMed_21979375_A2Down-0.0464358865
GSE35957Up0.0055679055
GSE36640Up0.0541022701
GSE54402Down-0.0028607815
GSE9593Up0.0694919606
GSE43922Up0.0389943773
GSE24585Down-0.1347648153
GSE37065Up0.0683646713
GSE28863_A1Up0.1044973191
GSE28863_A2Down-0.0087904344
GSE28863_A3Up0.2642210678
GSE28863_A4Up0.1430294126
GSE48662Down-0.0457240711

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MitotaneDB00648 APRD00494
MetyraponeDB01011 APRD01111 | EXPT02271

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.