HCSGD entry for CYP11A1

1. General information

Official gene symbolCYP11A1
Entrez ID1583
Gene full namecytochrome P450, family 11, subfamily A, polypeptide 1
Other gene symbolsCYP11A CYPXIA1 P450SCC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001101Response to acidIEAbiological_process
GO:0004497Monooxygenase activityIEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005739MitochondrionIEA ISScellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006700C21-steroid hormone biosynthetic processIDA TASbiological_process
GO:0006701Progesterone biosynthetic processIEAbiological_process
GO:0006703Estrogen biosynthetic processIEAbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0007617Mating behaviorIEAbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008203Cholesterol metabolic processIDA IMP ISSbiological_process
GO:0008386Cholesterol monooxygenase (side-chain-cleaving) activityIDA IEA ISSmolecular_function
GO:0009651Response to salt stressIEAbiological_process
GO:0010332Response to gamma radiationIEAbiological_process
GO:0014037Schwann cell differentiationIEAbiological_process
GO:0015485Cholesterol bindingIEAmolecular_function
GO:0016125Sterol metabolic processTASbiological_process
GO:0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEAmolecular_function
GO:0017085Response to insecticideIEAbiological_process
GO:0018879Biphenyl metabolic processIEAbiological_process
GO:0018894Dibenzo-p-dioxin metabolic processIEAbiological_process
GO:0018958Phenol-containing compound metabolic processIEAbiological_process
GO:0018963Phthalate metabolic processIEAbiological_process
GO:0020037Heme bindingIDA IEAmolecular_function
GO:0021549Cerebellum developmentIEAbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0030061Mitochondrial cristaIEAcellular_component
GO:0033197Response to vitamin EIEAbiological_process
GO:0033327Leydig cell differentiationIEAbiological_process
GO:0033591Response to L-ascorbic acidIEAbiological_process
GO:0033595Response to genisteinIEAbiological_process
GO:0042359Vitamin D metabolic processISSbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0043204PerikaryonIEAcellular_component
GO:0043279Response to alkaloidIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044344Cellular response to fibroblast growth factor stimulusIEAbiological_process
GO:0050756Fractalkine metabolic processIEAbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:0060014Granulosa cell differentiationIEAbiological_process
GO:0060135Maternal process involved in female pregnancyIEAbiological_process
GO:0060992Response to fungicideIEAbiological_process
GO:0061370Testosterone biosynthetic processIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071236Cellular response to antibioticIEAbiological_process
GO:0071276Cellular response to cadmium ionIEAbiological_process
GO:0071320Cellular response to cAMPIEAbiological_process
GO:0071347Cellular response to interleukin-1IEAbiological_process
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0071372Cellular response to follicle-stimulating hormone stimulusIEAbiological_process
GO:0071375Cellular response to peptide hormone stimulusIEAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.29615879720.92871172450.99530077891.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0379685826
GSE13712_SHEARUp0.1806805704
GSE13712_STATICUp0.1493446558
GSE19018Down-0.1108669906
GSE19899_A1Up0.0366786495
GSE19899_A2Up0.0803103566
PubMed_21979375_A1Up0.2696079778
PubMed_21979375_A2Down-0.0188956874
GSE35957Up0.4078111593
GSE36640Up0.0130441862
GSE54402Up0.0800445134
GSE9593Down-0.1136278953
GSE43922Up0.1374916227
GSE24585Down-0.0510276594
GSE37065Up0.2286214692
GSE28863_A1Down-0.0137882001
GSE28863_A2Up0.0082636737
GSE28863_A3Up0.1109199135
GSE28863_A4Up0.0081771435
GSE48662Up0.5245620199

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15611563Reduced testosterone was correlated with reductions in StAR, P450scc mRNA, and protein
15611563Significant decline in luteinizing hormone-stimulated intracellular cAMP levels was seen by 9 months, before significant reductions in testosterone, StAR, and P450scc
11191081Primary points of control in steroidogenesis are the transport of cholesterol from intracellular stores to the inner mitochondrial membrane, and the subsequent conversion of cholesterol to pregnenolone by the cholesterol side-chain cleavage enzyme (P450scc)
11191081To better understand the mechanism by which aging Leydig cells lose steroidogenic function, we examined the effect of aging on steroidogenic acute regulatory protein (StAR), an important Leydig cell cholesterol transfer protein, and on P450scc
11191081Significant reductions also were seen in the steady-state levels of mRNA for P450scc, of 29% and 50%, respectively
11191081Western blots revealed significant reductions in StAR protein, by 47% and 74%, respectively, and in P450scc protein, by 38% and 54%, respectively
111910814- , 3-, and 11-fold, respectively, whereas P450scc protein remained unchanged
11191081However, because P450scc is reduced in old Leydig cells, the reaction catalyzed by this enzyme would be rate-limiting under circumstances in which saturating amounts of cholesterol entered the mitochondria
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