HCSGD entry for CYP8B1
1. General information
| Official gene symbol | CYP8B1 |
|---|---|
| Entrez ID | 1582 |
| Gene full name | cytochrome P450, family 8, subfamily B, polypeptide 1 |
| Other gene symbols | CP8B CYP12 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004497 | Monooxygenase activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006699 | Bile acid biosynthetic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0008206 | Bile acid metabolic process | TAS | biological_process |
| GO:0008397 | Sterol 12-alpha-hydroxylase activity | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016125 | Sterol metabolic process | TAS | biological_process |
| GO:0016705 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | molecular_function |
| GO:0019825 | Oxygen binding | TAS | molecular_function |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0033778 | 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6477391626 | 0.6178777288 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0265239902 |
| GSE13712_SHEAR | Down | -0.1572234912 |
| GSE13712_STATIC | Up | 0.0184987485 |
| GSE19018 | Up | 0.2707281201 |
| GSE19899_A1 | Down | -0.1037816652 |
| GSE19899_A2 | Up | 0.2173444371 |
| PubMed_21979375_A1 | Up | 0.2147296608 |
| PubMed_21979375_A2 | Down | -0.1500949200 |
| GSE35957 | Up | 0.1700406713 |
| GSE36640 | Up | 0.0230487959 |
| GSE54402 | Up | 0.0298763130 |
| GSE9593 | Down | -0.0523373319 |
| GSE43922 | Up | 0.0917258575 |
| GSE24585 | Up | 0.1518697310 |
| GSE37065 | Down | -0.0733760954 |
| GSE28863_A1 | Down | -0.2651117150 |
| GSE28863_A2 | Down | -0.0892680064 |
| GSE28863_A3 | Down | -0.0085607599 |
| GSE28863_A4 | Up | 0.1050079477 |
| GSE48662 | Down | -0.0116354805 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-422a | MIMAT0001339 | MIRT000468 | qRT-PCR//Luciferase reporter assay | Non-Functional MTI | 20351063 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047552 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
