HCSGD entry for CYP7A1
1. General information
| Official gene symbol | CYP7A1 |
|---|---|
| Entrez ID | 1581 |
| Gene full name | cytochrome P450, family 7, subfamily A, polypeptide 1 |
| Other gene symbols | CP7A CYP7 CYPVII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006699 | Bile acid biosynthetic process | IDA IEA ISS TAS | biological_process |
| GO:0006707 | Cholesterol catabolic process | ISS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0008123 | Cholesterol 7-alpha-monooxygenase activity | ISS | molecular_function |
| GO:0008206 | Bile acid metabolic process | TAS | biological_process |
| GO:0016125 | Sterol metabolic process | TAS | biological_process |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0042632 | Cholesterol homeostasis | ISS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | ISS | cellular_component |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0070857 | Regulation of bile acid biosynthetic process | IDA ISS | biological_process |
| GO:0071333 | Cellular response to glucose stimulus | IDA | biological_process |
| GO:0071397 | Cellular response to cholesterol | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4262938300 | 0.7009899548 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2072879456 |
| GSE13712_SHEAR | Down | -0.1135487907 |
| GSE13712_STATIC | Down | -0.0904575841 |
| GSE19018 | Up | 0.1116205200 |
| GSE19899_A1 | Up | 0.2481532462 |
| GSE19899_A2 | Down | -0.0264812523 |
| PubMed_21979375_A1 | Down | -0.4554117386 |
| PubMed_21979375_A2 | Up | 0.2108437113 |
| GSE35957 | Up | 0.0656801905 |
| GSE36640 | Down | -0.0668399246 |
| GSE54402 | Down | -0.0737561257 |
| GSE9593 | Up | 0.1399970663 |
| GSE43922 | Up | 0.0085256343 |
| GSE24585 | Up | 0.0624784540 |
| GSE37065 | Up | 0.2876261668 |
| GSE28863_A1 | Down | -0.0552293102 |
| GSE28863_A2 | Up | 0.0096749527 |
| GSE28863_A3 | Up | 0.0210972600 |
| GSE28863_A4 | Up | 0.0190717323 |
| GSE48662 | Up | 0.0462305334 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT000012 | qRT-PCR//Luciferase reporter assay | Functional MTI | 20351063 |
| hsa-miR-422a | MIMAT0001339 | MIRT000469 | qRT-PCR//Luciferase reporter assay | Functional MTI | 20351063 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018408 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048926 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
