HCSGD entry for ADRBK2
1. General information
| Official gene symbol | ADRBK2 |
|---|---|
| Entrez ID | 157 |
| Gene full name | adrenergic, beta, receptor kinase 2 |
| Other gene symbols | BARK2 GRK3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004703 | G-protein coupled receptor kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0031623 | Receptor internalization | IDA | biological_process |
| GO:0038032 | Termination of G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0047696 | Beta-adrenergic receptor kinase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0663293378 | 0.9737472588 | 0.5548443456 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0366942168 |
| GSE13712_SHEAR | Down | -0.3348194363 |
| GSE13712_STATIC | Down | -0.1097905294 |
| GSE19018 | Up | 0.0878223848 |
| GSE19899_A1 | Up | 0.1342422513 |
| GSE19899_A2 | Up | 0.3697553253 |
| PubMed_21979375_A1 | Up | 0.2694703855 |
| PubMed_21979375_A2 | Up | 0.4022728803 |
| GSE35957 | Up | 0.2113618482 |
| GSE36640 | Up | 1.4208418146 |
| GSE54402 | Up | 0.3299245546 |
| GSE9593 | Up | 0.0521649169 |
| GSE43922 | Up | 0.3559348790 |
| GSE24585 | Up | 0.0355299824 |
| GSE37065 | Up | 0.0027387710 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.2479238843 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine triphosphate | DB00171 | NUTR00017 | EXPT00007 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT026831 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040362 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042753 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
