HCSGD entry for ADRBK1

1. General information

Official gene symbolADRBK1
Entrez ID156
Gene full nameadrenergic, beta, receptor kinase 1
Other gene symbolsBARK1 BETA-ARK1 GRK2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002029Desensitization of G-protein coupled receptor protein signaling pathwayISSbiological_process
GO:0003108Negative regulation of the force of heart contraction by chemical signalIMPbiological_process
GO:0004672Protein kinase activityISSmolecular_function
GO:0004703G-protein coupled receptor kinase activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007165Signal transductionIEA TASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007213G-protein coupled acetylcholine receptor signaling pathwayISSbiological_process
GO:0007217Tachykinin receptor signaling pathwayIDAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0016020MembraneISScellular_component
GO:0018105Peptidyl-serine phosphorylationISSbiological_process
GO:0018107Peptidyl-threonine phosphorylationIEAbiological_process
GO:0031623Receptor internalizationIDAbiological_process
GO:0031694Alpha-2A adrenergic receptor bindingISSmolecular_function
GO:0031755Edg-2 lysophosphatidic acid receptor bindingIDAmolecular_function
GO:0033605Positive regulation of catecholamine secretionISSbiological_process
GO:0038032Termination of G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045988Negative regulation of striated muscle contractionIMPbiological_process
GO:0047696Beta-adrenergic receptor kinase activityIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88297380800.46589167580.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0132515787
GSE13712_SHEARDown-0.1031880185
GSE13712_STATICDown-0.1997043161
GSE19018Up0.0823015734
GSE19899_A1Down-0.0008057254
GSE19899_A2Up0.1218335659
PubMed_21979375_A1Down-0.1016652907
PubMed_21979375_A2Down-0.0055685083
GSE35957Down-0.1658746341
GSE36640Up0.0441274919
GSE54402Up0.0195983961
GSE9593Down-0.0481834655
GSE43922Down-0.0667199909
GSE24585Down-0.3900647523
GSE37065Up0.0604354650
GSE28863_A1Down-0.0680695592
GSE28863_A2Down-0.0331641910
GSE28863_A3Down-0.0630119313
GSE28863_A4Up0.0232886323
GSE48662Up0.4665325253

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.