HCSGD entry for CYP2C9

1. General information

Official gene symbolCYP2C9
Entrez ID1559
Gene full namecytochrome P450, family 2, subfamily C, polypeptide 9
Other gene symbolsCPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004497Monooxygenase activityIDA NASmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008202Steroid metabolic processIMPbiological_process
GO:0008395Steroid hydroxylase activityIMPmolecular_function
GO:0016098Monoterpenoid metabolic processIDAbiological_process
GO:0016491Oxidoreductase activityIDAmolecular_function
GO:0017144Drug metabolic processIDA IMPbiological_process
GO:0018675(S)-limonene 6-monooxygenase activityIEAmolecular_function
GO:0018676(S)-limonene 7-monooxygenase activityIEAmolecular_function
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0019373Epoxygenase P450 pathwayTASbiological_process
GO:0019627Urea metabolic processIDAbiological_process
GO:0020037Heme bindingIEAmolecular_function
GO:0032787Monocarboxylic acid metabolic processIDAbiological_process
GO:0034875Caffeine oxidase activityIDAmolecular_function
GO:0042737Drug catabolic processIMPbiological_process
GO:0042738Exogenous drug catabolic processIDAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDA TAScellular_component
GO:0043603Cellular amide metabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0052741(R)-limonene 6-monooxygenase activityIEAmolecular_function
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0070989Oxidative demethylationIDAbiological_process
GO:0097267Omega-hydroxylase P450 pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68246563580.91757082560.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0359029012
GSE13712_SHEARDown-0.0742908857
GSE13712_STATICUp0.0852806253
GSE19018Up0.0589642089
GSE19899_A1Up0.1648214917
GSE19899_A2Up0.1630604912
PubMed_21979375_A1Up0.0698362396
PubMed_21979375_A2Up0.0039792727
GSE35957Up0.1094234919
GSE36640Up0.0228191692
GSE54402Up0.0246701592
GSE9593Up0.0167553714
GSE43922Up0.0460466337
GSE24585Down-0.0619087512
GSE37065Down-0.0903670880
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0947749427

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1672448CHEMBL33979P11712
CHEMBL1262CHEMBL33979P11712
CHEMBL1200324CHEMBL33979P11712
CHEMBL1909050CHEMBL33979P11712
CHEMBL1479CHEMBL33979P11712
CHEMBL24944CHEMBL33979P11712
CHEMBL60889CHEMBL33979P11712
CHEMBL1016CHEMBL33979P11712
CHEMBL472CHEMBL33979P11712
CHEMBL1221CHEMBL33979P11712
CHEMBL485549CHEMBL33979P11712
CHEMBL1466CHEMBL33979P11712
CHEMBL1255837CHEMBL33979P11712
CHEMBL1097558CHEMBL33979P11712
CHEMBL475534CHEMBL33979P11712
CHEMBL191CHEMBL33979P11712
CHEMBL808CHEMBL33979P11712
CHEMBL1089CHEMBL33979P11712
CHEMBL163CHEMBL33979P11712
CHEMBL799CHEMBL33979P11712
CHEMBL456807CHEMBL33979P11712
CHEMBL81CHEMBL33979P11712
CHEMBL1200604CHEMBL33979P11712
CHEMBL388590CHEMBL33979P11712
CHEMBL18329CHEMBL33979P11712
CHEMBL1428CHEMBL33979P11712
CHEMBL91CHEMBL33979P11712
CHEMBL61CHEMBL33979P11712
CHEMBL603CHEMBL33979P11712
CHEMBL710CHEMBL33979P11712
CHEMBL434063CHEMBL33979P11712
CHEMBL104CHEMBL33979P11712
CHEMBL252556CHEMBL33979P11712
CHEMBL1480CHEMBL33979P11712
CHEMBL408CHEMBL33979P11712
CHEMBL364713CHEMBL33979P11712
CHEMBL10CHEMBL33979P11712
CHEMBL165CHEMBL33979P11712
CHEMBL437002CHEMBL33979P11712
CHEMBL12131CHEMBL33979P11712
CHEMBL1201139CHEMBL33979P11712
CHEMBL1909048CHEMBL33979P11712
CHEMBL460291CHEMBL33979P11712
CHEMBL1109CHEMBL33979P11712
CHEMBL413CHEMBL33979P11712
CHEMBL1909051CHEMBL33979P11712
CHEMBL115769CHEMBL33979P11712
CHEMBL1078CHEMBL33979P11712
CHEMBL1909049CHEMBL33979P11712
CHEMBL942CHEMBL33979P11712
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  • Drugs

Name

Drug

Accession number

4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-OneDB02507 EXPT02984
Heme CDB03317 EXPT01722

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16818632In NHFs cultured in low versus normal serum, MYC induced increased expression of CYP2C9, a gene product well known to be associated with ROS production
16818632Specific inhibition of CYP2C9 by small interfering RNA was shown to partially inhibit MYC-induced ROS production
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