HCSGD entry for CYP2C8
1. General information
| Official gene symbol | CYP2C8 |
|---|---|
| Entrez ID | 1558 |
| Gene full name | cytochrome P450, family 2, subfamily C, polypeptide 8 |
| Other gene symbols | CPC8 CYPIIC8 MP-12/MP-20 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004497 | Monooxygenase activity | IDA IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006082 | Organic acid metabolic process | IDA | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0016705 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | molecular_function |
| GO:0017144 | Drug metabolic process | IDA | biological_process |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0019373 | Epoxygenase P450 pathway | TAS | biological_process |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0034875 | Caffeine oxidase activity | IDA | molecular_function |
| GO:0042738 | Exogenous drug catabolic process | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
| GO:0070330 | Aromatase activity | IEA | molecular_function |
| GO:0070989 | Oxidative demethylation | IDA | biological_process |
| GO:0097267 | Omega-hydroxylase P450 pathway | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8111040310 | 0.8405529881 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0740002890 |
| GSE13712_SHEAR | Down | -0.2187848790 |
| GSE13712_STATIC | Down | -0.0310011141 |
| GSE19018 | Down | -0.0026801610 |
| GSE19899_A1 | Up | 0.0386446497 |
| GSE19899_A2 | Up | 0.0065138920 |
| PubMed_21979375_A1 | Down | -0.0567340041 |
| PubMed_21979375_A2 | Down | -0.0155129533 |
| GSE35957 | Up | 0.0999605665 |
| GSE36640 | Up | 0.0911192009 |
| GSE54402 | Up | 0.0163626754 |
| GSE9593 | Up | 0.0050748551 |
| GSE43922 | Up | 0.0158600504 |
| GSE24585 | Up | 0.1147211197 |
| GSE37065 | Up | 0.0093961923 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0309268654 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Isoniazid | DB00951 | APRD01055 | EXPT01940 |
| Palmitic Acid | DB03796 | EXPT01393 | EXPT02607 |
| (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE | DB08607 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT006955 | qRT-PCR//Western blot | Functional MTI | 22723340 |
| hsa-miR-107 | MIMAT0000104 | MIRT006956 | qRT-PCR//Western blot | Functional MTI | 22723340 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
