HCSGD entry for CYP2B6
1. General information
| Official gene symbol | CYP2B6 |
|---|---|
| Entrez ID | 1555 |
| Gene full name | cytochrome P450, family 2, subfamily B, polypeptide 6 |
| Other gene symbols | CPB6 CYP2B CYP2B7 CYP2B7P CYPIIB6 EFVM IIB1 P450 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004497 | Monooxygenase activity | IDA IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006805 | Xenobiotic metabolic process | IDA TAS | biological_process |
| GO:0008202 | Steroid metabolic process | IMP | biological_process |
| GO:0016705 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | molecular_function |
| GO:0016712 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | IEA | molecular_function |
| GO:0017144 | Drug metabolic process | IDA IMP | biological_process |
| GO:0020037 | Heme binding | IDA IEA | molecular_function |
| GO:0042180 | Cellular ketone metabolic process | IDA | biological_process |
| GO:0042738 | Exogenous drug catabolic process | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5901828844 | 0.9114707762 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0785969668 |
| GSE13712_SHEAR | Down | -0.1894654477 |
| GSE13712_STATIC | Up | 0.0020744612 |
| GSE19018 | Down | -0.0410485990 |
| GSE19899_A1 | Up | 0.1520449723 |
| GSE19899_A2 | Down | -0.0747790064 |
| PubMed_21979375_A1 | Up | 0.1276077865 |
| PubMed_21979375_A2 | Up | 0.1168545687 |
| GSE35957 | Up | 0.2508403489 |
| GSE36640 | Up | 0.1878665755 |
| GSE54402 | Up | 0.0035284284 |
| GSE9593 | Up | 0.1321678295 |
| GSE43922 | Up | 0.0072213116 |
| GSE24585 | Up | 0.0933785701 |
| GSE37065 | Down | -0.0597769385 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.2168697419 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 4-(4-Chlorophenyl)Imidazole | DB02974 | EXPT01008 |
| Cyclohexyl-pentyl-maltoside | DB04664 | - |
| 1-(biphenyl-4-ylmethyl)-1H-imidazole | DB08369 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7e-5p | MIMAT0000066 | MIRT051706 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26202037 | Mobilized CD34+ve cells expressed both stem and multiple hepatocyte markers, including mRNA of albumin and CYP2B6 (cytochrome P2 B6) |
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