HCSGD entry for CYP2A6

1. General information

Official gene symbolCYP2A6
Entrez ID1548
Gene full namecytochrome P450, family 2, subfamily A, polypeptide 6
Other gene symbolsCPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005506Iron ion bindingIEAmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005881Cytoplasmic microtubuleIDAcellular_component
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0008202Steroid metabolic processIMPbiological_process
GO:0008389Coumarin 7-hydroxylase activityIDAmolecular_function
GO:0009804Coumarin metabolic processIDAbiological_process
GO:0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEAmolecular_function
GO:0016712Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEAmolecular_function
GO:0017144Drug metabolic processIDA IMPbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0020037Heme bindingIDA IEAmolecular_function
GO:0042738Exogenous drug catabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046226Coumarin catabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71929289160.85106207970.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0220021736
GSE13712_SHEARDown-0.0391815305
GSE13712_STATICDown-0.0418816229
GSE19018Up0.0524595847
GSE19899_A1Up0.0666675267
GSE19899_A2Up0.0765236807
PubMed_21979375_A1Up0.1153708369
PubMed_21979375_A2Up0.0092817584
GSE35957Up0.2753926815
GSE36640Up0.1044394084
GSE54402Down-0.0125391433
GSE9593Down-0.0694832968
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.2349941191
GSE28863_A2Up0.0038938083
GSE28863_A3Down-0.0041941612
GSE28863_A4Up0.1885794241
GSE48662--

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2H-1-BENZOPYRAN-2-ONEDB04665 -
N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINEDB07609 -
N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINEDB07617 -
(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINEDB07621 -
4,4'-DIPYRIDYL DISULFIDEDB07623 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.