HCSGD entry for CYP1B1
1. General information
| Official gene symbol | CYP1B1 |
|---|---|
| Entrez ID | 1545 |
| Gene full name | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| Other gene symbols | CP1B CYPIB1 GLC3A P4501B1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0004497 | Monooxygenase activity | TAS | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006725 | Cellular aromatic compound metabolic process | IEA | biological_process |
| GO:0006805 | Xenobiotic metabolic process | IDA TAS | biological_process |
| GO:0007601 | Visual perception | TAS | biological_process |
| GO:0008202 | Steroid metabolic process | IDA | biological_process |
| GO:0009404 | Toxin metabolic process | IEA | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0016125 | Sterol metabolic process | TAS | biological_process |
| GO:0016712 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | IDA | molecular_function |
| GO:0019369 | Arachidonic acid metabolic process | TAS | biological_process |
| GO:0019373 | Epoxygenase P450 pathway | TAS | biological_process |
| GO:0019825 | Oxygen binding | TAS | molecular_function |
| GO:0020037 | Heme binding | IDA TAS | molecular_function |
| GO:0043542 | Endothelial cell migration | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | TAS | biological_process |
| GO:0061298 | Retina vasculature development in camera-type eye | IEA | biological_process |
| GO:0070330 | Aromatase activity | IEA | molecular_function |
| GO:0071603 | Endothelial cell-cell adhesion | IEA | biological_process |
| GO:0097267 | Omega-hydroxylase P450 pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0028574294 | 0.0169080734 | 0.1432579048 | 0.2544524871 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3237508482 |
| GSE13712_SHEAR | Down | -1.1416463313 |
| GSE13712_STATIC | Up | 0.0063473070 |
| GSE19018 | Down | -1.6270753748 |
| GSE19899_A1 | Up | 0.2880571160 |
| GSE19899_A2 | Up | 2.0291703802 |
| PubMed_21979375_A1 | Up | 1.3799196217 |
| PubMed_21979375_A2 | Up | 2.9377063174 |
| GSE35957 | Up | 0.0942159066 |
| GSE36640 | Down | -4.3617841579 |
| GSE54402 | Down | -2.6220093721 |
| GSE9593 | Up | 0.3496738755 |
| GSE43922 | Up | 1.4026736459 |
| GSE24585 | Up | 0.5215424284 |
| GSE37065 | Up | 0.0807460709 |
| GSE28863_A1 | Up | 0.2164734585 |
| GSE28863_A2 | Up | 1.1224313954 |
| GSE28863_A3 | Up | 0.8850954848 |
| GSE28863_A4 | Down | -0.5685191247 |
| GSE48662 | Down | -0.1333297789 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2-Methoxyestradiol | DB02342 | EXPT01362 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002598 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002598 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT004826 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Other | Functional MTI | 16982751 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019543 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024201 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-27b-3p | MIMAT0000419 | 1 | hsa-miR-27b | {Western blot}{Western blot} | {underexpression by anti-miRNA oligonucleotides}{overexpression by miRNA precursor transfection} | 16982751 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26721440 | Further analysis with iTraq identified CYP1B1, a component of the cytochrome p450 system, as a potential molecule mediating ROS generation in pNO40 deficient MSCs |
| 24885022 | Further, we presented evidence suggesting that neither endogenous AhR expression levels nor downstream induction of AhR target genes CYP1A1 and CYP1B1 is required for AF-mediated growth inhibition in these cells |
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