HCSGD entry for CYP1A2

1. General information

Official gene symbolCYP1A2
Entrez ID1544
Gene full namecytochrome P450, family 1, subfamily A, polypeptide 2
Other gene symbolsCP12 P3-450 P450(PA)
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004497Monooxygenase activityIDAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006706Steroid catabolic processIMPbiological_process
GO:0006778Porphyrin-containing compound metabolic processIEAbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0009055Electron carrier activityTASmolecular_function
GO:0009403Toxin biosynthetic processIDAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0009820Alkaloid metabolic processIDAbiological_process
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0016098Monoterpenoid metabolic processIDAbiological_process
GO:0016491Oxidoreductase activityIDAmolecular_function
GO:0016712Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIMPmolecular_function
GO:0017144Drug metabolic processIDAbiological_process
GO:0018894Dibenzo-p-dioxin metabolic processIEAbiological_process
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0019373Epoxygenase P450 pathwayTASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0020037Heme bindingIDAmolecular_function
GO:0030324Lung developmentIEAbiological_process
GO:0032259MethylationTASbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032451Demethylase activityIDAmolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032787Monocarboxylic acid metabolic processIDAbiological_process
GO:0034875Caffeine oxidase activityIDAmolecular_function
GO:0042737Drug catabolic processIMPbiological_process
GO:0042738Exogenous drug catabolic processIDAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045333Cellular respirationIEAbiological_process
GO:0046483Heterocycle metabolic processIDAbiological_process
GO:0050665Hydrogen peroxide biosynthetic processIEAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0070330Aromatase activityIEAmolecular_function
GO:0070989Oxidative demethylationIDAbiological_process
GO:0071276Cellular response to cadmium ionIEAbiological_process
GO:0071615Oxidative deethylationIDAbiological_process
GO:0097267Omega-hydroxylase P450 pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49334340260.78607782000.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1939049037
GSE13712_SHEARDown-0.0841647965
GSE13712_STATICUp0.0177907810
GSE19018Up0.2576956436
GSE19899_A1Up0.0276753390
GSE19899_A2Up0.2474575789
PubMed_21979375_A1Down-0.3616133510
PubMed_21979375_A2Down-0.0840662805
GSE35957Up0.1637168104
GSE36640Down-0.1025196370
GSE54402Up0.0232250568
GSE9593Down-0.0361530781
GSE43922Up0.0391664209
GSE24585Up0.1855240769
GSE37065Down-0.0185844955
GSE28863_A1Down-0.1643361150
GSE28863_A2Down-0.2882995784
GSE28863_A3Up0.2048402618
GSE28863_A4Up0.2518590811
GSE48662Down-0.1013362124

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IsoniazidDB00951 APRD01055 | EXPT01940
2-PHENYL-4H-BENZO[H]CHROMEN-4-ONEDB07453 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT052168CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.