HCSGD entry for SRFBP1
1. General information
| Official gene symbol | SRFBP1 |
|---|---|
| Entrez ID | 153443 |
| Gene full name | serum response factor binding protein 1 |
| Other gene symbols | BUD22 P49 Rlb1 STRAP p49/STRAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0400671365 | 0.2115976027 | 0.4493426076 | 0.8878464052 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2044475281 |
| GSE13712_SHEAR | Up | 0.6137355456 |
| GSE13712_STATIC | Up | 0.4988919920 |
| GSE19018 | Down | -1.5295972772 |
| GSE19899_A1 | Down | -0.0224216906 |
| GSE19899_A2 | Up | 0.5740145466 |
| PubMed_21979375_A1 | Up | 1.4295696607 |
| PubMed_21979375_A2 | Up | 0.5694972417 |
| GSE35957 | Down | -0.2525013070 |
| GSE36640 | Down | -0.9999382689 |
| GSE54402 | Up | 0.6335798087 |
| GSE9593 | Up | 0.1026344430 |
| GSE43922 | Up | 0.1988607029 |
| GSE24585 | Down | -0.3468757469 |
| GSE37065 | Up | 0.2294309741 |
| GSE28863_A1 | Down | -0.0598264175 |
| GSE28863_A2 | Up | 0.5766961809 |
| GSE28863_A3 | Down | -0.4636787890 |
| GSE28863_A4 | Down | -0.1475216748 |
| GSE48662 | Down | -0.3793555750 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25183317 | BACKGROUND: The protein p49/STRAP (SRFBP1) is a transcription cofactor of serum response factor (SRF) which regulates cytoskeletal and muscle-specific genes |
| 25183317 | RESULTS: Two conserved domains were found in the p49/STRAP protein |
| 25183317 | The BUD22 domain was conserved among mammalian p49/STRAP proteins, and yeast cellular morphogenesis proteins, which is involved in ribosome biogenesis that affects growth rate and cell size |
| 25183317 | Overexpression of p49/STRAP reduced actin content in cultured cells and resulted in smaller cell size versus control cells |
| 25183317 | Increased expression of p49/STRAP in transgenic mice resulted in newborns with malformations, which included asymmetric abdominal and thoracic cavities, and substantial changes in cardiac morphology |
| 25183317 | CONCLUSIONS: Since p49/STRAP is a co-factor of SRF, our data suggest that p49/STRAP likely regulates cell size and morphology through SRF target genes |
| 25183317 | The observed increase in p49/STRAP expression during cellular aging may contribute to observed morphological changes in senescence |
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