HCSGD entry for CTSL1

1. General information

Official gene symbolCTSL1
Entrez ID1514
Gene full namecathepsin L1
Other gene symbolsCATL CTSL MEP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002250Adaptive immune responseIEPbiological_process
GO:0004197Cysteine-type endopeptidase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005634NucleusTAScellular_component
GO:0005764LysosomeIDAcellular_component
GO:0006508ProteolysisIDA IEAbiological_process
GO:0008234Cysteine-type peptidase activityIDA IEAmolecular_function
GO:0019882Antigen processing and presentationTASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0036021Endolysosome lumenTAScellular_component
GO:0042393Histone bindingIDAmolecular_function
GO:0043202Lysosomal lumenTAScellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0071888Macrophage apoptotic processNASbiological_process
GO:0097067Cellular response to thyroid hormone stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00167975380.98410377650.10943762381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.5231460513
GSE13712_SHEARUp0.2970760093
GSE13712_STATICUp0.3708193075
GSE19018Down-0.1619790092
GSE19899_A1Up1.4462290466
GSE19899_A2Up0.9289456422
PubMed_21979375_A1Up0.8366572454
PubMed_21979375_A2Up1.1995993119
GSE35957Down-0.7693202824
GSE36640Up0.1372304681
GSE54402Up0.5217886833
GSE9593Up0.7678882804
GSE43922Up1.3049674196
GSE24585Up0.3357639925
GSE37065Up0.6309796871
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.4540592326

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Cysteinesulfonic AcidDB03661 EXPT02415
BIPHENYL-4-YL-ACETALDEHYDEDB07477 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT005214pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25394905Here, using models of oncogene-induced and replicative senescence, we report novel histone H3 tail cleavage events mediated by the protease Cathepsin L
20060114We also investigated p53 expression and its relation to apoptosis and apoptosis-related cathepsin L and ferritin in the carotid lesions
20060114Furthermore, p53 expression was significantly correlated with the expression of ferritin, lysosomal cathepsin L, and apoptosis
16306232Aged neurons displayed a senescent phenotype and a marked up-regulation of cathepsin-L expression
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