HCSGD entry for CTSK

1. General information

Official gene symbolCTSK
Entrez ID1513
Gene full namecathepsin K
Other gene symbolsCTS02 CTSO CTSO1 CTSO2 PKND PYCD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001957Intramembranous ossificationIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0004197Cysteine-type endopeptidase activityTASmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0008234Cysteine-type peptidase activityIEA TASmolecular_function
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0036021Endolysosome lumenTAScellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0045453Bone resorptionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00023560650.21770405000.04367183100.8982894341

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up2.0172028481
GSE13712_SHEARUp0.3871184573
GSE13712_STATICDown-3.0348838048
GSE19018Down-0.2956698093
GSE19899_A1Up1.2694064581
GSE19899_A2Up2.0742597713
PubMed_21979375_A1Up0.9772236094
PubMed_21979375_A2Up3.7059936154
GSE35957Up0.8323931689
GSE36640Down-0.5548511461
GSE54402Down-1.0469941457
GSE9593Up2.2346224572
GSE43922Up1.5756140310
GSE24585Up0.0876546453
GSE37065Up0.8306476076
GSE28863_A1Down-0.2027001850
GSE28863_A2Up2.4485619016
GSE28863_A3Down-0.6707727379
GSE28863_A4Down-0.0679233115
GSE48662Up0.2554663910

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

[1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]PentylcarbamateDB01858 EXPT01501
3-amino-5-phenylpentaneDB02869 EXPT02332
1-[N[(Phenylmethoxy)Carbonyl]-L-Leucyl-4-[[N/N-[(Phenylmethoxy)Carbonyl]-/Nl-Leucyl]Amino]-3-Pyrrolidinone/NDB03405 EXPT02520
N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamideDB03456 EXPT02301
Benzofuran-2-Carboxylic Acid {(S)-3-Methyl-1-[3-Oxo-1-(Pyridin-2-Ylsulfonyl)Azepan-4-Ylcarbamoyl]Butyl}AmideDB03642 EXPT00107
1,5-Bis(N-Benzyloxycarbonyl-L-Leucinyl)CarbohydrazideDB03891 EXPT01880
N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-LeucinamideDB04234 EXPT02267
1-[2-(3-Biphenyl)-4-Methylvaleryl)]Amino-3-(2-Pyridylsulfonyl)Amino-2-PropanoneDB04244 EXPT01807
Tert-Butyl(1s)-1-Cyclohexyl-2-OxoethylcarbamateDB04523 EXPT03026
MIV-701DB05736 -
1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamineDB07563 -
(1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATEDB07592 -
1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATEDB07593 -
6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrileDB07965 -
9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILEDB07967 -
N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDEDB08270 -
(1R,2R)-N-(2-AMINOETHYL)-2-{[(4-METHOXYPHENYL)SULFONYL]METHYL}CYCLOHEXANECARBOXAMIDEDB08287 -
TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATEDB08594 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-296-3pMIMAT0004679MIRT038461CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.