HCSGD entry for CTSE
1. General information
| Official gene symbol | CTSE |
|---|---|
| Entrez ID | 1510 |
| Gene full name | cathepsin E |
| Other gene symbols | CATE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004190 | Aspartic-type endopeptidase activity | IDA IEA | molecular_function |
| GO:0005768 | Endosome | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007586 | Digestion | TAS | biological_process |
| GO:0016540 | Protein autoprocessing | IEA | biological_process |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7230226131 | 0.7756310323 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1856631553 |
| GSE13712_SHEAR | Down | -0.1499406175 |
| GSE13712_STATIC | Down | -0.0358823278 |
| GSE19018 | Up | 0.3398192062 |
| GSE19899_A1 | Up | 0.1191326805 |
| GSE19899_A2 | Down | -0.0043118658 |
| PubMed_21979375_A1 | Down | -0.0583006689 |
| PubMed_21979375_A2 | Down | -0.0607409974 |
| GSE35957 | Up | 0.0603215323 |
| GSE36640 | Up | 0.1055805386 |
| GSE54402 | Up | 0.1205422789 |
| GSE9593 | Down | -0.0042887104 |
| GSE43922 | Up | 0.0156482577 |
| GSE24585 | Down | -0.2036835429 |
| GSE37065 | Up | 0.1118116013 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0255046999 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-25-3p | MIMAT0000081 | MIRT050230 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 2738038 | Age-related and phenylhydrazine-induced activation of the membrane-associated cathepsin E in human erythrocytes |
| 2738038 | We examined the effects of cell aging and phenylhydrazine-induced oxidant damage on erythrocyte cathepsin E, which is present as a latent, membrane-associated enzyme in normal human erythrocytes |
| 2738038 | When young erythrocytes isolated from human mature erythrocytes by Percoll density gradient centrifugation were aged in vitro, the membrane-associated cathepsin E was progressively released from the membrane as an active enzyme |
| 2738038 | When phenylhydrazine was incubated with the erythrocytes, it also caused the activation and solubilization of cathepsin E in a dose-dependent and time-dependent manner |
| 2738038 | Both aging and phenylhydrazine-treatment were accompanied with an increase in the association of the cytosolic proteins, primarily hemoglobin, with the membrane, which occurred prior to the release of cathepsin E from the membrane |
| 2738038 | Thus, the primary mechanism for activation of cathepsin E in the intact cells seems to be through lesion of the membrane framework that results from increased binding of hemoglobin to the membrane |
| 2738038 | The relation between the cathepsin E activation and the membrane protein breakdown is discussed |
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