HCSGD entry for ADRA2A

1. General information

Official gene symbolADRA2A
Entrez ID150
Gene full nameadrenoceptor alpha 2A
Other gene symbolsADRA2 ADRA2R ADRAR ALPHA2AAR ZNF32
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001819Positive regulation of cytokine productionIDAbiological_process
GO:0002526Acute inflammatory responseIEAbiological_process
GO:0004938Alpha2-adrenergic receptor activityIDA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006260DNA replicationIEAbiological_process
GO:0006928Cellular component movementTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007194Negative regulation of adenylate cyclase activityISSbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007266Rho protein signal transductionTASbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0010700Negative regulation of norepinephrine secretionNAS TASbiological_process
GO:0016323Basolateral plasma membraneTAScellular_component
GO:0019229Regulation of vasoconstrictionIEAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030036Actin cytoskeleton organizationTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0030818Negative regulation of cAMP biosynthetic processIDA ISSbiological_process
GO:0031692Alpha-1B adrenergic receptor bindingISSmolecular_function
GO:0031696Alpha-2C adrenergic receptor bindingIPImolecular_function
GO:0031996Thioesterase bindingIPImolecular_function
GO:0032147Activation of protein kinase activityIDAbiological_process
GO:0032148Activation of protein kinase B activityIDAbiological_process
GO:0032795Heterotrimeric G-protein bindingIDAmolecular_function
GO:0032811Negative regulation of epinephrine secretionNASbiological_process
GO:0032870Cellular response to hormone stimulusIGIbiological_process
GO:0035625Epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0042593Glucose homeostasisIMPbiological_process
GO:0042596Fear responseIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043235Receptor complexIDAcellular_component
GO:0043268Positive regulation of potassium ion transportISSbiological_process
GO:0043406Positive regulation of MAP kinase activityIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045202SynapseIEAcellular_component
GO:0045741Positive regulation of epidermal growth factor-activated receptor activityIDAbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0045955Negative regulation of calcium ion-dependent exocytosisICbiological_process
GO:0046676Negative regulation of insulin secretionIMPbiological_process
GO:0046982Protein heterodimerization activityIPI ISSmolecular_function
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0050892Intestinal absorptionTASbiological_process
GO:0050955ThermoceptionIEAbiological_process
GO:0050995Negative regulation of lipid catabolic processIGIbiological_process
GO:0051044Positive regulation of membrane protein ectodomain proteolysisIDAbiological_process
GO:0051379Epinephrine bindingIDAmolecular_function
GO:0051380Norepinephrine bindingIDAmolecular_function
GO:0051926Negative regulation of calcium ion transportISSbiological_process
GO:0061179Negative regulation of insulin secretion involved in cellular response to glucose stimulusIMPbiological_process
GO:0070473Negative regulation of uterine smooth muscle contractionIEAbiological_process
GO:0071878Negative regulation of adrenergic receptor signaling pathwayISSbiological_process
GO:0071881Adenylate cyclase-inhibiting adrenergic receptor signaling pathwayIDAbiological_process
GO:0071882Phospholipase C-activating adrenergic receptor signaling pathwayIDAbiological_process
GO:0071883Activation of MAPK activity by adrenergic receptor signaling pathwayIDAbiological_process
GO:0090303Positive regulation of wound healingIMPbiological_process
GO:1901020Negative regulation of calcium ion transmembrane transporter activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10250674750.52766536230.66666408991.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3128616896
GSE13712_SHEARUp0.1196943277
GSE13712_STATICDown-0.1197924334
GSE19018Up0.0184324144
GSE19899_A1Up0.1882038781
GSE19899_A2Up0.1981351231
PubMed_21979375_A1Up0.0214408388
PubMed_21979375_A2Down-0.1822719905
GSE35957Down-0.6902453962
GSE36640Up0.1545312276
GSE54402Up0.2790380328
GSE9593Down-0.3307899331
GSE43922Up0.1565672203
GSE24585Up0.6133329277
GSE37065Down-0.0928327919
GSE28863_A1Up1.0340435339
GSE28863_A2Down-0.0425429768
GSE28863_A3Down-0.7137364744
GSE28863_A4Down-0.0245400955
GSE48662Down-0.0346930095

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029792MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.