HCSGD entry for TICAM1

1. General information

Official gene symbolTICAM1
Entrez ID148022
Gene full nametoll-like receptor adaptor molecule 1
Other gene symbolsIIAE6 MyD88-3 PRVTIRB TICAM-1 TRIF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002281Macrophage activation involved in immune responseIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004871Signal transducer activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030890Positive regulation of B cell proliferationIEAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIEAbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0032092Positive regulation of protein bindingIEAbiological_process
GO:0032481Positive regulation of type I interferon productionIEAbiological_process
GO:0032755Positive regulation of interleukin-6 productionIEAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIEAbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043330Response to exogenous dsRNAIMPbiological_process
GO:0043496Regulation of protein homodimerization activityIEAbiological_process
GO:0045080Positive regulation of chemokine biosynthetic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045359Positive regulation of interferon-beta biosynthetic processIEAbiological_process
GO:0045429Positive regulation of nitric oxide biosynthetic processIEAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0097190Apoptotic signaling pathwayIEAbiological_process
GO:0097342RipoptosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00991786030.98772269670.25423151751.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0369290219
GSE13712_SHEARUp1.2910554931
GSE13712_STATICUp0.5584218989
GSE19018Up0.0346685234
GSE19899_A1Up0.1447528169
GSE19899_A2Up1.1008422109
PubMed_21979375_A1Up1.0442820913
PubMed_21979375_A2Up0.4386093815
GSE35957Up0.2526634561
GSE36640Up0.4014526602
GSE54402Up0.3216168578
GSE9593Up0.3810334747
GSE43922Up0.3144035190
GSE24585Up0.1430948298
GSE37065Up0.1438314332
GSE28863_A1Down-0.3073696142
GSE28863_A2Down-0.1761172329
GSE28863_A3Up0.4141356534
GSE28863_A4Up0.0842858193
GSE48662Up0.1697598682

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-221-3pMIMAT0000278MIRT005475Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI21236259
hsa-miR-193b-3pMIMAT0002819MIRT041391CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.