HCSGD entry for CSTF2
1. General information
| Official gene symbol | CSTF2 |
|---|---|
| Entrez ID | 1478 |
| Gene full name | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa |
| Other gene symbols | CstF-64 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005847 | MRNA cleavage and polyadenylation specificity factor complex | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006369 | Termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0006378 | MRNA polyadenylation | TAS | biological_process |
| GO:0006379 | MRNA cleavage | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0031124 | MRNA 3'-end processing | TAS | biological_process |
| GO:0071920 | Cleavage body | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1730611603 | 0.4438889556 | 0.8172125583 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1097621731 |
| GSE13712_SHEAR | Up | 0.1010651925 |
| GSE13712_STATIC | Up | 0.0316472775 |
| GSE19018 | Down | -0.1638962012 |
| GSE19899_A1 | Up | 0.1002072025 |
| GSE19899_A2 | Up | 0.1655470083 |
| PubMed_21979375_A1 | Up | 1.5376083652 |
| PubMed_21979375_A2 | Up | 0.2372354810 |
| GSE35957 | Down | -0.4488719140 |
| GSE36640 | Down | -0.4110018071 |
| GSE54402 | Up | 0.5854176257 |
| GSE9593 | Down | -0.3861114117 |
| GSE43922 | Up | 0.3816476634 |
| GSE24585 | Down | -0.2069351635 |
| GSE37065 | Up | 0.1312144257 |
| GSE28863_A1 | Down | -0.0905788610 |
| GSE28863_A2 | Up | 0.2063010205 |
| GSE28863_A3 | Down | -0.6414321141 |
| GSE28863_A4 | Up | 0.1782405538 |
| GSE48662 | Down | -0.4608315056 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019784 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045489 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21080485 | Immortalized cells had significantly higher levels of methyl-accepting proteins, such as cleavage stimulation factor 2 (CstF2) and heterogeneous nuclear ribonucleoprotein (hnRNP) R, than young cells |
| 21080485 | However, senescent cells contained hypomethylated CstF2, hnRNP K, and chaperone containing TCP1 subunit 7, as well as decreased hnRNP R level |
| 21080485 | Further, significant reduction of arginine modification in CstF2 and chaperone containing TCP1 subunit 7 was observed in prematurely senescent fibroblasts, induced by treatment with adenosine dialdehyde, a transmethylation inhibitor, or subcytotoxic concentration of H(2)O(2) |
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