HCSGD entry for CST1
1. General information
| Official gene symbol | CST1 |
|---|---|
| Entrez ID | 1469 |
| Gene full name | cystatin SN |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004869 | Cysteine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0010951 | Negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000491737 | 0.6974274078 | 0.0188913043 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9610644709 |
| GSE13712_SHEAR | Down | -1.4427523020 |
| GSE13712_STATIC | Down | -2.2826958983 |
| GSE19018 | Up | 0.0264039422 |
| GSE19899_A1 | Up | 3.0515788779 |
| GSE19899_A2 | Up | 2.1342125435 |
| PubMed_21979375_A1 | Up | 4.6666301445 |
| PubMed_21979375_A2 | Up | 5.6247706854 |
| GSE35957 | Down | -0.0758508400 |
| GSE36640 | Up | 1.9580219162 |
| GSE54402 | Up | 2.4356566105 |
| GSE9593 | Up | 0.3461275138 |
| GSE43922 | Up | 5.1335282828 |
| GSE24585 | Up | 0.2714214983 |
| GSE37065 | Up | 0.1029746042 |
| GSE28863_A1 | Down | -0.5457594499 |
| GSE28863_A2 | Up | 0.1945157329 |
| GSE28863_A3 | Up | 0.2336165753 |
| GSE28863_A4 | Up | 0.3529779767 |
| GSE48662 | Up | 0.2843298259 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018277 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21636832 | Novel expression of CST1 as candidate senescence marker |
| 21636832 | Here, we report on the consistent and strong upregulation of CST1 expression during cellular senescence, independent of the initial trigger |
| 21636832 | CST1 expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts and various human tumor cell lines |
| 21636832 | We discuss these results in light of the known function of CST1 as a potent inhibitor of lysosomal cysteine proteases |
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