HCSGD entry for VCAN
1. General information
| Official gene symbol | VCAN |
|---|---|
| Entrez ID | 1462 |
| Gene full name | versican |
| Other gene symbols | CSPG2 ERVR GHAP PG-M WGN WGN1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005539 | Glycosaminoglycan binding | TAS | molecular_function |
| GO:0005540 | Hyaluronic acid binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0008037 | Cell recognition | TAS | biological_process |
| GO:0008347 | Glial cell migration | IDA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0030204 | Chondroitin sulfate metabolic process | TAS | biological_process |
| GO:0030206 | Chondroitin sulfate biosynthetic process | TAS | biological_process |
| GO:0030207 | Chondroitin sulfate catabolic process | TAS | biological_process |
| GO:0030208 | Dermatan sulfate biosynthetic process | TAS | biological_process |
| GO:0030246 | Carbohydrate binding | IEA | molecular_function |
| GO:0031012 | Extracellular matrix | IDA ISS | cellular_component |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9568721059 | 0.0015279283 | 0.9999902473 | 0.0758803774 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2865925805 |
| GSE13712_SHEAR | Down | -1.8159602543 |
| GSE13712_STATIC | Down | -0.7739201271 |
| GSE19018 | Down | -0.5375599155 |
| GSE19899_A1 | Down | -0.2703191743 |
| GSE19899_A2 | Down | -1.0986759817 |
| PubMed_21979375_A1 | Down | -1.1272451247 |
| PubMed_21979375_A2 | Down | -0.8852250439 |
| GSE35957 | Up | 0.3247717462 |
| GSE36640 | Down | -0.2927938524 |
| GSE54402 | Down | -0.2227319925 |
| GSE9593 | Down | -1.6601697796 |
| GSE43922 | Up | 0.1258017267 |
| GSE24585 | Down | -0.9059590623 |
| GSE37065 | Down | -0.1628778018 |
| GSE28863_A1 | Up | 0.4434401697 |
| GSE28863_A2 | Up | 0.3444262654 |
| GSE28863_A3 | Down | -0.0036709433 |
| GSE28863_A4 | Down | -0.3404977708 |
| GSE48662 | Down | -0.3776646096 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Hyaluronic acid | DB08818 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19164294 | Versican/PG-M Assembles Hyaluronan into Extracellular Matrix and Inhibits CD44-mediated Signaling toward Premature Senescence in Embryonic Fibroblasts |
| 19164294 | Versican/PG-M is a large chondroitin sulfate proteoglycan of the extracellular matrix which interacts with hyaluronan at the N-terminal G1 domain, composed of A, B, and B' subdomains |
| 19164294 | Recently, we generated knock-in mice Cspg2(Delta3/Delta3), whose versican, without the A subdomain, has decreased hyaluronan (HA) binding affinity, thereby exhibiting reduced deposition of versican in the extracellular matrix |
| 19164294 | Whereas the extracellular matrix of the wild type fibroblasts exhibited a network structure of hyaluronan and versican, that of the Cspg2(Delta3/Delta3) fibroblasts exhibited approximately 35 and approximately 85% deposition of versican and HA, without such a structure |
| 19164294 | These results demonstrate that versican is essential for matrix assembly involving hyaluronan and that diminished versican deposition increases free hyaluronan fragments that interact with CD44 and increase phosphorylation of ERK1/2, leading to cellular senescence |
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