HCSGD entry for CSNK2A1
1. General information
| Official gene symbol | CSNK2A1 |
|---|---|
| Entrez ID | 1457 |
| Gene full name | casein kinase 2, alpha 1 polypeptide |
| Other gene symbols | CK2A1 CKII CSNK2A3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016580 | Sin3 complex | IDA | cellular_component |
| GO:0016581 | NuRD complex | IDA | cellular_component |
| GO:0030177 | Positive regulation of Wnt signaling pathway | IMP | biological_process |
| GO:0030307 | Positive regulation of cell growth | IDA | biological_process |
| GO:0031519 | PcG protein complex | IDA | cellular_component |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0045732 | Positive regulation of protein catabolic process | IDA | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0051879 | Hsp90 protein binding | TAS | molecular_function |
| GO:0061077 | Chaperone-mediated protein folding | TAS | biological_process |
| GO:0071174 | Mitotic spindle checkpoint | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0743251662 | 0.9811983625 | 0.5786908930 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2414372533 |
| GSE13712_SHEAR | Down | -0.0310075147 |
| GSE13712_STATIC | Up | 0.1130445686 |
| GSE19018 | Up | 0.4131266302 |
| GSE19899_A1 | Up | 0.3779443771 |
| GSE19899_A2 | Up | 0.6783744484 |
| PubMed_21979375_A1 | Up | 0.4289074947 |
| PubMed_21979375_A2 | Up | 0.0779009156 |
| GSE35957 | Down | -0.1053494119 |
| GSE36640 | Down | -0.1596388960 |
| GSE54402 | Up | 0.3808538221 |
| GSE9593 | Up | 0.2213117931 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.2247039770 |
| GSE28863_A2 | Up | 0.0388155888 |
| GSE28863_A3 | Down | -0.1388315083 |
| GSE28863_A4 | Up | 0.0393427870 |
| GSE48662 | Up | 0.0384273451 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| (5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid | DB01765 | EXPT01927 |
| 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One | DB02170 | EXPT02205 |
| 1,8-Di-Hydroxy-4-Nitro-Anthraquinone | DB03035 | EXPT01762 |
| Benzamidine | DB03127 | EXPT00669 |
| 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone | DB03924 | EXPT02206 |
| Phosphoaminophosphonic Acid-Adenylate Ester | DB04395 | EXPT00524 |
| Tetrabromo-2-Benzotriazole | DB04462 | EXPT03020 |
| DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE | DB04719 | - |
| S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE | DB04720 | - |
| N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE | DB04721 | - |
| 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE | DB07715 | - |
| 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE | DB07802 | - |
| 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one | DB08338 | - |
| N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE | DB08340 | - |
| 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE | DB08345 | - |
| 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE | DB08353 | - |
| 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE | DB08354 | - |
| 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE | DB08360 | - |
| N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE | DB08362 | - |
| 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole | DB08473 | - |
| 1,2,5,8-tetrahydroxyanthracene-9,10-dione | DB08660 | - |
| Ellagic Acid | DB08846 | DB08468 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-216b-5p | MIMAT0004959 | MIRT007207 | Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23137536 |
| hsa-miR-337-3p | MIMAT0000754 | MIRT007208 | Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23137536 |
| hsa-miR-760 | MIMAT0004957 | MIRT007209 | Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23137536 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT007210 | Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23137536 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT030638 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039530 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039801 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047136 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047431 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047540 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051854 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052272 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052591 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 11 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26703243 | Regulation of protein kinase CK2 catalytic activity by protein kinase C and phospholipase D2 |
| 25064843 | PLD2 overexpression increased protein kinase CK2 (also known as casein kinase 2) (CK2) activity |
| 23768371 | An inhibitor of the protein kinase CKII (CKII) was purified from leaves of Glycine max (L |
| 23768371 | Coumestrol inhibited the phosphotransferase activity of CKII toward beta-casein, with an IC50 of about 5 muM |
| 23523798 | We previously reported that CKII downregulation induces senescence in human lung fibroblast IMR-90 and colon cancer HCT116 cells |
| 23523798 | CKIIalpha knock-down or CKII inhibitor treatment strikingly increased phosphorylation of mTOR, p70S6K, an mTOR substrate, and AKT, whereas CKIIalpha overexpression reduced this phosphorylation event |
| 23523798 | This result indicated that CKII inhibition activated the PI3K-AKT-mTOR pathway |
| 23137536 | MiR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells |
| 23137536 | To investigate the role of microRNAs (miRNAs) in CKII downregulation during senescence, we employed computational algorithms |
| 21968188 | Here, CKII inhibition induced acetylation of p53 at K382 in HCT116 and HEK293 cells |
| 21968188 | CKII inhibition reduced SIRT1 activity in cells |
| 21968188 | CKII phosphorylated and activated human SIRT1 in vitro |
| 21968188 | These results reveal that CKII downregulation induces p53 stabilization by negatively regulating SIRT1 deacetylase activity during senescence |
| 21702981 | BACKGROUND: Protein kinase CK2 is a highly conserved, ubiquitous protein serine/threonine kinase that phosphorylates many substrates and has a global role in numerous biological and pathological processes |
| 19855935 | The p53-p21(Cip1/WAF1) pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells |
| 19855935 | We have previously shown that the down-regulation of protein kinase CKII activity is tightly associated with cellular senescence of human fibroblast IMR-90 cells |
| 19855935 | A senescent marker appeared after staining for senescence-associated beta-galactosidase activity in wild-type HCT116 cells treated with CKII inhibitor or CKIIalpha siRNA, but this response was almost abolished in p53- or p21(Cip1/WAF1)-null cells |
| 19855935 | Increased cellular levels of p53 and p21(Cip1/WAF1) protein occurred with the inhibition of CKII |
| 19855935 | CKII inhibition upregulated p53 and p21(Cip1/WAF1) expression at post-transcriptional level and transcription level, respectively |
| 19855935 | RB phosphorylation significantly decreased in cells treated with CKII inhibitor |
| 19855935 | Taken together, this study shows that the activation of the p53-p21(Cip1/WAF1) pathway acts as a major mediator of cellular senescence induced by CKII inhibition |
| 19826041 | Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells |
| 19027835 | Silencing of the CKII alpha and CKII alpha' genes during cellular senescence is mediated by DNA methylation |
| 19027835 | Previously we reported that down-regulation of CKII activity is tightly associated with cellular senescence and that the mRNA and protein levels of CKII alpha decrease during senescence |
| 19027835 | The present study demonstrates that the mRNA and protein levels of CKII alpha' also decrease during senescence |
| 19027835 | Knockdown of CKII alpha' in IMR-90 cells by RNA interference induced the senescent phenotype |
| 19027835 | However, bisulfite sequencing analysis revealed that the methylation status of the CpG islands within the reported CKII alpha and CKII alpha' promoters was not associated with senescence |
| 19027835 | Instead, senescence-dependent hypermethylation was observed in the region ranging from position +1112 to +1128 of the CKII alpha gene and at positions -527 and +829 of the CKII alpha' gene |
| 16442104 | Downregulation of protein kinase CKII is associated with cellular senescence |
| 16442104 | Protein kinase CKII (CKII) plays a critical role in cell growth and proliferation |
| 16442104 | In this study, we examine how CKII activity is regulated during cellular senescence |
| 16442104 | Our results demonstrate that CKII activity apparently decreases during both replicative and H2O2-induced senescence in human diploid fibroblast IMR-90 cells |
| 16442104 | Treatment of IMR-90 cells with CKII inhibitors 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and apigenin led cells to acquire a senescent phenotype as judged by the senescence-associated beta-galactosidase marker and overexpression of p53 and p21(Waf-1) |
| 16442104 | In parallel, CKII activity was transcriptional downregulated in rat liver and testis with advancing age |
| 16442104 | Taken together, these results suggest that downregulation of CKII activity is tightly associated not only with cellular senescence but also with organism aging |
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