HCSGD entry for GSC
1. General information
| Official gene symbol | GSC |
|---|---|
| Entrez ID | 145258 |
| Gene full name | goosecoid homeobox |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001085 | RNA polymerase II transcription factor binding | ISS | molecular_function |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | ISS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0007369 | Gastrulation | NAS | biological_process |
| GO:0021904 | Dorsal/ventral neural tube patterning | IEA | biological_process |
| GO:0023019 | Signal transduction involved in regulation of gene expression | IEA | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IEA | biological_process |
| GO:0030900 | Forebrain development | IEA | biological_process |
| GO:0042474 | Middle ear morphogenesis | ISS | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0048644 | Muscle organ morphogenesis | IEA | biological_process |
| GO:0048704 | Embryonic skeletal system morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3440284298 | 0.7548280157 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0994219017 |
| GSE13712_SHEAR | Down | -0.1118752203 |
| GSE13712_STATIC | Up | 0.2135233159 |
| GSE19018 | Down | -0.1272927956 |
| GSE19899_A1 | Down | -0.1050661477 |
| GSE19899_A2 | Up | 0.0166255309 |
| PubMed_21979375_A1 | Up | 0.0538919368 |
| PubMed_21979375_A2 | Up | 0.1416041219 |
| GSE35957 | Down | -0.2749401047 |
| GSE36640 | Down | -0.0650180891 |
| GSE54402 | Down | -0.0628127507 |
| GSE9593 | Up | 0.0279941063 |
| GSE43922 | Up | 0.3210765667 |
| GSE24585 | Down | -0.0273712702 |
| GSE37065 | Down | -0.0482059071 |
| GSE28863_A1 | Down | -0.1257912240 |
| GSE28863_A2 | Up | 0.0419702793 |
| GSE28863_A3 | Up | 0.5059554176 |
| GSE28863_A4 | Up | 0.0203947553 |
| GSE48662 | Up | 0.5670116419 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019699 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25470527 | Insulin signaling, which controls cellular nutrient sensing and organismal aging, regulates the G2 phase of Drosophila female germ line stem cell (GSC) division cycle in response to diet; furthermore, this signaling pathway is attenuated with age |
| 25470527 | Here, we report that aging results in the accumulation of tumorous GSCs, accompanied by a decline in GSC number and proliferation rate |
| 25470527 | In addition, GSC tumors (which escape the normal stem cell regulatory microenvironment, known as the niche) still respond to aging in a similar manner to normal GSCs, suggesting that niche signals are not required for GSCs to sense or respond to aging |
| 25157949 | If GSCs were present in adult female ovaries, it could be postulated that the occurrence of menopause is not due to the exhaustion of a fixed supply of oocytes but instead is a result of GSC and somatic cell aging |
| 18371381 | BMP signaling activity from the niche significantly decreases with age, and increasing BMP signaling can prolong GSC life span and promote their proliferation |
| 18371381 | Finally, overexpression of SOD, an enzyme that helps eliminate free oxygen species, in either GSCs or their niche alone can prolong GSC life span and increase GSC proliferation |
| 18267001 | Here we show in female Drosophila that germline stem cell (GSC) division rate progressively declines with age, which is accompanied by reduced decapentaplegic (dpp) niche signaling pathway activation within GSCs |
| 18267001 | Genetically increasing dpp expression delays GSC activity decline and transiently increases egg production |
| 18267001 | We conclude that age-related decline of reproduction is caused by both decreased GSC activity and increased incidence of cell death during oogenesis, while decreased GSC activity is attributed to declined signaling from the regulatory niche |
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