HCSGD entry for CSNK1A1
1. General information
| Official gene symbol | CSNK1A1 |
|---|---|
| Entrez ID | 1452 |
| Gene full name | casein kinase 1, alpha 1 |
| Other gene symbols | CK1 CK1a CKIa HLCDGP1 PRO2975 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0000902 | Cell morphogenesis | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IEA TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005847 | MRNA cleavage and polyadenylation specificity factor complex | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016607 | Nuclear speck | IDA | cellular_component |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8913865431 | 0.2113375024 | 0.9999902473 | 0.8871793301 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1957978893 |
| GSE13712_SHEAR | Up | 0.1548303536 |
| GSE13712_STATIC | Down | -0.0051270529 |
| GSE19018 | Up | 0.0771380277 |
| GSE19899_A1 | Down | -0.1343669670 |
| GSE19899_A2 | Down | -0.1793539025 |
| PubMed_21979375_A1 | Down | -0.0434201006 |
| PubMed_21979375_A2 | Up | 0.0784689650 |
| GSE35957 | Down | -0.1831167307 |
| GSE36640 | Up | 0.2433303880 |
| GSE54402 | Down | -0.0522600017 |
| GSE9593 | Down | -0.0516893680 |
| GSE43922 | Down | -0.2385588804 |
| GSE24585 | Up | 0.3193765686 |
| GSE37065 | Down | -0.0711406782 |
| GSE28863_A1 | Up | 0.1885041981 |
| GSE28863_A2 | Up | 0.1465895848 |
| GSE28863_A3 | Down | -0.5270890612 |
| GSE28863_A4 | Down | -0.2936368667 |
| GSE48662 | Down | -0.2404419644 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT006267 | Luciferase reporter assay | Functional MTI | 22350414 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT006267 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT006267 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021178 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030896 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039466 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042900 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23739040 | Recently, a new role of p53 together with CSNK1A1 in colon cancer invasiveness has been described in mice |
| 23739040 | Moreover, survival effects of CSNK1A1 together with p53 were also studied |
| 23739040 | Expression of CSNK1A1 modified p53 survival effects |
| 23739040 | Patients with low CSNK1A1 expression and non-functional p53 had a very poor survival both in the univariate (Log Rank p<0 |
| 21331045 | Inducing the ablation of Csnk1a1 (the gene encoding CKIalpha) in the gut triggers massive Wnt activation, surprisingly without causing tumorigenesis |
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