HCSGD entry for CSK

1. General information

Official gene symbolCSK
Entrez ID1445
Gene full namec-src tyrosine kinase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004713Protein tyrosine kinase activityIEA TASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDA IEA TAScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIPI TAScellular_component
GO:0005911Cell-cell junctionIEAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008022Protein C-terminus bindingTASmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0010989Negative regulation of low-density lipoprotein particle clearanceIEAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0019903Protein phosphatase bindingIEAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0032715Negative regulation of interleukin-6 productionIEAbiological_process
GO:0033673Negative regulation of kinase activityIEAbiological_process
GO:0034332Adherens junction organizationIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042997Negative regulation of Golgi to plasma membrane protein transportIDAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043406Positive regulation of MAP kinase activityIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045779Negative regulation of bone resorptionIEAbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0050765Negative regulation of phagocytosisIEAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0060368Regulation of Fc receptor mediated stimulatory signaling pathwayIEAbiological_process
GO:0070064Proline-rich region bindingIEAmolecular_function
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0071375Cellular response to peptide hormone stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19005256640.20564358120.84789706780.8801210894

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0681635423
GSE13712_SHEARDown-0.0260083047
GSE13712_STATICDown-0.0200802531
GSE19018Down-0.5147902472
GSE19899_A1Down-0.2598079057
GSE19899_A2Up1.0556574779
PubMed_21979375_A1Up1.6813367761
PubMed_21979375_A2Up1.4363617047
GSE35957Down-1.0197340097
GSE36640Down-0.5634760815
GSE54402Up0.2686147595
GSE9593Down-0.5027900090
GSE43922Up0.0930339625
GSE24585Down-0.6235534593
GSE37065Down-0.0970417500
GSE28863_A1Up0.0378043285
GSE28863_A2Down-0.0072537741
GSE28863_A3Up0.1487195097
GSE28863_A4Up0.1006419251
GSE48662Up0.1162398646

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

StaurosporineDB02010 EXPT02970 | EXPT02972
TG100801DB05075 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-140-5pMIMAT0000431MIRT003960MicroarrayFunctional MTI (Weak)17875710
hsa-miR-24-3pMIMAT0000080MIRT030606MicroarrayFunctional MTI (Weak)19748357
hsa-miR-1180-3pMIMAT0005825MIRT035928CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.